Project Grant DP2AR087515
- The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and...
- This federal Project Grant award of $121,303.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The University of Texas Southwestern Medical Center in Dallas, Texas. The grant supports research to investigate the mechanisms by which transcriptional condensates, which are dynamic protein assemblies, function during cell state transitions and drive cell fate determination. The research project...
- This federal Project Grant award of $2,880,000 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to Baylor College of Medicine. The funding will support a 3-year research project titled "Uncovering the Role of Extracellular Condensates as Triggers of Neuroinflammation". The project aims to investigate how certain neuropathological proteins can mimic the behavior of innate immune signals, triggering neuroinflammation in...
- This federal Project Grant award, valued at $758,594 and spanning from September 1, 2025 to August 31, 2027, was provided by the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the molecular basis of the TREX-2 mRNA nuclear export pathway. The research aims to elucidate the differential roles and interaction networks of the TREX-2...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- This federal Project Grant award of $458,189 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding how specific membrane-remodeling factors regulate oligodendrocyte membrane dynamics and myelination in the central nervous system. The research aims to elucidate the mechanisms by which these factors shape...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,178,675 to investigate the spatial organization and conformational ensembles of alpha-synuclein (a-syn) amyloids inside cells. The project aims to identify the prevalent a-syn amyloid conformations and their abundances in biological settings, which could enhance understanding of amyloid propagation and aid in identifying biologically relevant structures. Key objectives include...
- The University of Texas Health Science Center at San Antonio was awarded a $116,586 Project Grant by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports research investigating the mechanisms of neuronal nuclear mechanotransduction, which is the ability of neurons to detect and respond to mechanical stimuli, in both physiological conditions...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This $3,081,936 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the University of California, San Diego (UCSD) to investigate the mechanisms underlying TDP-43 proteinopathies, which are associated with amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease,...
This federal Project Grant award of $1,476,000.00 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) and is being performed by the University of Texas Southwestern Medical Center (UT Southwestern) in Dallas, TX. The award will fund research to investigate the role of membraneless cellular compartments, known as biomolecular condensates, in neuromuscular diseases and other age-related disorders. The project aims to develop new technologies to directly link condensate biology to disease pathobiology, leveraging the institution's expertise in cellular models of protein aggregation. This research has the potential to provide important insights into the fundamental cell biology underlying neurodegenerative and neuromuscular conditions. The award period runs from September 1, 2025 through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 9/2/25 |