Project Grant R01GM157478
- The University of Texas Health Science Center at Houston (UTHealth) was awarded a $868,584 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, which runs from September 1, 2025 to August 31, 2027, will fund research to investigate how RNA modifications regulate adaptive mRNA translation. The research aims to elucidate the roles of the TRMT1L RNA methyltransferase and its interaction with...
- This federal Project Grant award, valued at $222,708.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at the University of California, Davis to study the structure and organization of nuclear messenger RNAs (mRNAs) and their interactions with RNA binding proteins (RBPs) prior to export from the cell nucleus. The central hypothesis is that mRNA structure is a critical factor...
- This federal Project Grant award of $1,476,000.00 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) and is being performed by the University of Texas Southwestern Medical Center (UT Southwestern) in Dallas, TX. The award will fund research to investigate the role of membraneless cellular compartments, known as biomolecular condensates, in neuromuscular diseases and other age-related disorders. The project aims to develop new...
- This federal Project Grant award of $574,000, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research and advanced training across diverse areas of biomedical science. The award, with a performance period from May 1, 2025 to Feb 28, 2030, will fund the University of Texas Southwestern Medical Center's research project to understand the general working principles of...
- This $228,340 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the role of endoplasmic reticulum (ER)-to-actin tethering in cell migration, a critical process for tissue development and repair. The research aims to determine the mechanisms by which the ER interacts with the actin cytoskeleton and spatially coordinates ER-actin...
- This $357,385 federal Project Grant award was provided by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) to the University of Texas at Arlington. The grant aims to uncover the mechanistic details of how the overlapping networks of RNA interference (RNAi) and chromatin modifying pathways maintain appropriate gene regulation during stress in the C. elegans germline model system. The project will employ interdisciplinary approaches including genetics,...
- This federal Project Grant award of $398,444, awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to systematically dissect the contributions of the cellular environment on the polymodal regulation of transient receptor potential (TRP) ion channels. The University of Texas at San Antonio (UTSA) will conduct cell-based experiments and in vitro reconstitution...
- This federal Project Grant award of $404,569.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to The University of Texas Southwestern Medical Center to conduct research on the role of Z-DNA in RNA polymerase III transcriptional regulation. The research aims to define the physiological functions of the Z-DNA structure, investigate the Z-DNA binding capacity of the POLR3F subunit, and...
- This federal Project Grant award of $121,303.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The University of Texas Southwestern Medical Center in Dallas, Texas. The grant supports research to investigate the mechanisms by which transcriptional condensates, which are dynamic protein assemblies, function during cell state transitions and drive cell fate determination. The research project...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
This federal Project Grant award, valued at $758,594 and spanning from September 1, 2025 to August 31, 2027, was provided by the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the molecular basis of the TREX-2 mRNA nuclear export pathway. The research aims to elucidate the differential roles and interaction networks of the TREX-2 complex and a new TREX-2LENG8 variant in facilitating the nuclear export of cellular and influenza virus mRNAs. Additionally, the project will investigate the RNA-protein interactions that determine TREX-2 or TREX-2LENG8 dependency. The findings from this interdisciplinary research are expected to establish the molecular mechanisms by which these complexes mediate the recruitment and nuclear export of various mRNAs.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $758.6k | 8/29/25 |