Project Grant DAMD170310520

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $425,118 to Virginia Polytechnic Institute & State University (Virginia Tech) will support the development of a new portable biosensor capable of detecting a wide range of toxins and emerging environmental threats. The biosensor will use living microbial reporter cells and surface-enhanced Raman scattering (SERS) technology to rapidly identify chemical, nanotechnology, and...

This $199,979 EAGER award from the National Science Foundation's Biological Sciences (CFDA 47.074) program will develop an open-source large language model to rapidly identify, verify, prioritize, summarize, and predict outcomes of emerging disease threats across humans, animals, and plants. The project, titled "The BioThreats Emergence, Analysis, and Communications Network (BEACON)", aims to create a specialized AI/machine learning system that can process vast datasets to detect...

This Project Grant award from the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) provides $459,353 to the University of Toledo to discover and characterize novel cyanotoxins associated with harmful cyanobacterial blooms in western Lake Erie. The research aims to: 1) optimize liquid chromatography with native fluorescence and mass spectrometry detection to structurally analyze microcystins, anabaenopeptins, and cyanopeptolins; 2) perform structural analyses...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $202,488.00 to Cedars-Sinai Medical Center to conduct research on the function of TOX protein isoforms in T cell and innate lymphoid cell (ILC) development. The key products and services to be delivered include: A comprehensive analysis of T cell and ILC development in a novel mouse model (D37) that...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $304,780 to Nanoplasmonics LLC supports the development of a portable, cost-effective detection system for harmful mycotoxins in the food supply. The key innovations include synthetic molecular imprinted polymers that function as artificial antibodies to selectively detect mycotoxins, combined with plasmonic nanoparticles to enhance fluorescence signals for improved sensitivity....

This Project Grant award of $532,947 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development and validation of a unified, cloud-based data processing workflow and database called LC-BINBASE for high-resolution LC-MS/MS metabolomics and lipidomics data. The project, led by researchers from UC Davis, University of Michigan, and Pacific Northwest National Laboratory, aims to harmonize and...

The National Institute of Environmental Health Sciences (NIEHS) awarded Nexilico, Inc. a $275,765 Project Grant (CFDA 93.113 - Environmental Health) to develop a predictive computational-experimental platform to characterize microbial biotransformation of xenobiotic compounds and identify naturally occurring gut microbial strains that can mitigate xenobiotic toxicity as novel probiotics. The project aims to provide cost-effective yet accurate predictions to identify microbial species capable...

This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...

This Project Grant award, funded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), aims to develop new computational methods and workflows to improve the identification of tumor-associated antigens (TAAs) for the design of safer and more effective T-cell-based cancer immunotherapies. The $414,649 award will fund the integration of existing NCI resources, such as PVACtools, with new bioinformatics approaches for structural modeling and...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,096 to Michigan State University to elucidate the mechanisms of tetrodotoxin (TTX) biosynthesis in microbial symbionts. The research aims to identify the genes involved in TTX production by sequencing the genomes of TTX-producing bacteria found on newts, using experimental evolution approaches, and...