This $532,947.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support a collaborative research effort led by scientists at the University of California, Davis (UC Davis), the University of Michigan, and Pacific Northwest National Laboratory. The project aims to develop and validate a unified, cloud-based data processing workflow and database, called LC-BINBASE, for harmonizing and standardizing high-resolution liquid chromatography-mass spectrometry (LC-MS/MS) metabolomics and lipidomics data across different laboratories and instrument platforms. Through experimental and computational robustness testing, the team will demonstrate that metabolomics data can be made more reproducible and standardized by applying the LC-BINBASE database and associated algorithms for metabolite annotation and confidence scoring. The validated usability of the LC-BINBASE system for biomedical research will be assessed through interlaboratory comparison studies on diverse sample types. The project will run from September 2024 through July 2028 and engage the broader scientific community through workshops and beta-testing opportunities.
Generated 1/28/25, 6:54 AM