This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $375,308 to Michigan State University to conduct computational modeling and simulation research on the interactions between natural products derived from plants, fungi, or bacteria and their environments. The key focus areas include:
Quantifying the binding interactions between natural products and human proteins or cell...
This Project Grant award of $185,726 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855, Allergy and Infectious Diseases Research) aims to investigate the biosynthetic mechanisms underlying a novel class of antimicrobial peptides (AMPs). The overarching goal is to gain a sophisticated understanding of the biosynthetic gene cluster (BGC) that produces this AMP family, which is widely distributed across diverse bacteria and represents a valuable resource for future...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $220,340 to the Whitehead Institute for Biomedical Research to conduct research focused on understanding the molecular mechanisms that regulate the chronic stage of the Toxoplasma gondii parasite. The key objectives are to investigate how the parasite's BFD1 and BFD2 proteins interact to drive and maintain the chronic stage, as well as to...
This $300,000 federal Project Grant award under the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will be used by the University of California, Davis (UC Davis) to conduct research on the molecular mechanisms and evolution of Type 6 Secretion System (T6SS) toxins and immunity proteins in phytopathogenic Ralstonia bacteria. The central objective is to understand how these toxin warfare strategies enable Ralstonia to successfully compete against other...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $924,254 to Michigan State University to advance the understanding of a signal transduction system that influences the ability of Brucella abortus to survive stress and infect mammalian hosts. The research aims to 1) define the mechanism of stress signal detection by the Brucella sensory system, 2) characterize how the gene EIPB contributes...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $352,218 to Michigan State University (MSU) from July 2024 through April 2029 to conduct research on the regulation of upstream open reading frames (uORFs) in mRNA stability and translation.
The key objectives of this research project are to: 1) determine if nonsense-mediated mRNA decay (NMD) controls uORF-containing...
The federal Project Grant award of $616,816 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is supporting structural and functional studies of the ORFX-type progenitor toxin complex (PTC) associated with botulinum neurotoxins (BoNTs). The University of California, Irvine (UC Irvine) is conducting this research to elucidate the assembly mechanisms, structures, and potential regulatory factors of the ORFX-type PTC, which...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $193,750.00 to San Francisco State University (SFSU) to investigate the flavin-dependent thymidylate synthase (FDTS) enzyme as a potential target for new antimicrobial agents. The research aims to: 1) study the molecular mechanism of FDTS catalysis from Mycobacterium tuberculosis and Clostridioides difficile to develop a...
This National Institutes of Health (NIH) Project Grant award under the Biomedical Research and Research Training program (CFDA 93.859) provides $492,000 to The Trustees of Princeton University to expand the chemical space of microbial and microbiome natural products over a 5-year period from September 1, 2024 to August 31, 2029. The research aims to uncover cryptic natural products from diverse microbial genera, especially those found in the human microbiome, through genome-guided and...
This federal Project Grant award for $684,000 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to study the regulation of antibiotic tolerance in the nontuberculous mycobacterium Mycobacterium abscessus (Mabs).
The key objectives are to use cutting-edge proteomics techniques to investigate several proteases identified through a previous transposon sequencing (Tn-Seq) screen as...