Project Grant D71HS13415

The University of Louisville received a $159,701 project grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation to support research titled "COLLABORATIVE RESEARCH: SCH: OPTIMAL DESENSITIZATION PROTOCOL IN SUPPORT OF A KIDNEY PAIRED DONATION (KPD) SYSTEM." The award period is from October 1, 2021 to September 30, 2025. The research aims to develop an optimal desensitization protocol to support a kidney paired donation system. This...

The National Science Foundation awarded a $167,704 Project Grant to the University of Maryland, College Park under the Computer and Information Science and Engineering federal grant program (CFDA 47.070). The grant supports collaborative research to develop an optimal desensitization protocol to facilitate a kidney paired donation system. The research aims to advance the use of desensitization therapy to expand compatible donor options for kidney transplant candidates. Over a four-year period...

This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $1,800,000 to Missouri University of Science & Technology to develop an artificial intelligence decision support system for kidney transplant healthcare. The goal is to reduce kidney discard rates by at least 10% by embedding preferences and fairness considerations into AI models used to match donor kidneys with transplant centers. Two subawards totaling $XXX,XXX are provided to Saint...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $200,000.00 to New York University School of Medicine to conduct a case-cohort study investigating novel determinants of risk for living kidney donors. The key objectives are to: 1) use qualitative research to inform recruitment strategies and messaging to maximize participation of...

The National Institutes of Health Office of the Director awarded the University of Southern California a $2.9 million project grant under the Trans-NIH Research Support program (CFDA 93.310) to develop a synthetic kidney as a revolutionary solution to the shortage of kidneys available for transplantation. The three-year project will generate a transplantable synthetic kidney using stem cell and bioengineering technologies, then evaluate its growth, differentiation, vascularization and functional...

This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,411,136 to The Washington University in St. Louis to study the role of circadian rhythms in organ transplantation. The key objectives are to: Develop a model to predict biological rhythms and circadian clock function in organ donors, leveraging a partnership with the Mid-America Transplant Services organ procurement organization. This will generate the first...

The University of Louisville, through its Office of Research & Innovation Division, received a $464,073 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a generative AI-based system for accurate prediction of deceased donor liver-transplant (DDLT) outcomes and viability. The proposed system will use deep learning techniques to produce "virtual" Masson's trichrome stained slides from input hematoxylin and eosin...

The federal Project Grant award R01DK140129, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to optimize the allocation of kidneys from deceased African American donors with APOL1 high-risk genotypes. The primary goal is to identify clinically actionable approaches to determine which of these kidneys are truly "high risk" for...

This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), will fund a 5-year research project led by Dr. Carrie Thiessen at the University of Wisconsin-Madison. The $193,652 award aims to assess the impact of cognitive biases on patient and provider willingness to accept imperfect kidneys for transplantation. The project has three key objectives: Characterize the...

This Project Grant award of $799,354 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to comprehensively understand and pharmacologically target the necroptotic pathways in both the donor and recipient lungs to reduce the incidence of primary graft dysfunction (PGD) in lung transplantation. The research has two specific aims: 1) Exploring the role of TNF-α-induced autocrine necroptosis in monocyte-derived alveolar...