The National Institutes of Health Office of the Director awarded the University of Southern California a $2.9 million project grant under the Trans-NIH Research Support program (CFDA 93.310) to develop a synthetic kidney as a revolutionary solution to the shortage of kidneys available for transplantation. The three-year project will generate a transplantable synthetic kidney using stem cell and bioengineering technologies, then evaluate its growth, differentiation, vascularization and functional maturation after transplantation into chronic kidney disease and end-stage renal disease animal models. If successful, the synthetic kidney approach could halt progression of chronic kidney disease, provide alternative organ transplants for end-stage renal disease patients, and dramatically reduce related healthcare costs and complications by reducing dialysis needs. The University of California, San Diego will receive a subaward as part of the research collaboration to further the goals of developing a synthetic kidney to address the critical organ shortage.
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