Project Grant 2616040
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded San Diego State University Foundation $215,001 on September 1, 2026, to develop an integrated experimental and computational framework characterizing coronary blood vessel mechanics and their interaction with cardiac muscle under healthy and diseased conditions. The research will establish a multiscale model coupling coronary blood flow with cardiac mechanics, incorporating vascular impedance...
- Michigan State University was awarded a $416,955 Project Grant from the National Science Foundation's (NSF) Engineering (47.041) program to elucidate the myocardial energy demand-supply-production feedback system. Under this award running from June 2023 to May 2026, the University will utilize advanced computational modeling and experimental validation techniques to further understand the critical feedback loops that regulate cardiac function under both normal and pathological conditions....
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded $599,056 to the Regents of the University of Michigan (University of Michigan-Dearborn) on October 1, 2025, under the Engineering program (CFDA 47.041) to advance understanding of aqueous vein biomechanics in glaucoma treatment. The project uses whole globe perfusion, photoacoustic microscopy, and strain and flow modeling to study outflow in the aqueous veins lodged in the perilimbal sclera....
- This federal Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) provides $439,954 to Michigan State University (MSU) to develop advanced computational models of the heart that leverage machine learning and artificial intelligence. The goal is to create a multiscale modeling framework that can predict structural and functional changes in the heart due to disease conditions like pathological fibrosis. The...
- The National Heart, Lung, and Blood Institute awarded Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) $232,156 on August 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop physics- and image-based patient-specific computer models that predict the risk of left ventricular outflow tract obstruction in transcatheter mitral valve replacement procedures. The research addresses a critical limitation in current...
- This Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences provides $1,068,886 to Michigan State University under the Biological Sciences program (CFDA 47.074) from December 15, 2022 through November 30, 2025. The grant supports research examining the effects of shear flow on transient biomolecular interactions and aggregation in dense biological environments through integrated experimental and computational approaches. Michigan State University will...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Iowa State University $500,000 on August 1, 2026, under the Engineering program (CFDA 47.041) to develop multiscale computational models of vein graft failure in coronary bypass surgery. The project integrates computer modeling of blood flow and vascular remodeling to understand the mechanisms driving vein graft failure, which occurs at unacceptably high rates following coronary artery bypass...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded $199,991 to the Regents of the University of Michigan (doing business as University of Michigan-Dearborn) on May 15, 2026, under the Engineering Research Initiation program to design and build a microphysiological system that models cerebrospinal fluid dynamics in the brain to investigate mechanisms of neurodegeneration in Alzheimer's disease, Parkinson's disease, and amyotrophic...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded a $242,478 Project Grant to Michigan State University for collaborative research titled "Engineering Gradient Nanostructured Metals by Multi-Pass Plastic Wave Deformation." The three-year award runs from October 1, 2021 to September 30, 2024 and supports research under the NSF Engineering program (CFDA 47.041). The research aims to improve the quality of life and economic strength of the...
- Federal Grant Award Summary The University of Michigan received a $400,000 Project Grant from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041), effective September 1, 2025 through August 31, 2028. This collaborative research project delivers fundamental scientific knowledge and experimental/theoretical models investigating the mechanics of tissue boundary formation during embryonic development. The primary...
The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Michigan State University $370,721 on September 1, 2026, under the Engineering grant program (CFDA 47.041) to develop an integrated experimental and computational framework characterizing coronary blood vessel mechanics and their interaction with heart muscle tissue. The research establishes a multiscale model coupling coronary blood flow with cardiac mechanics, incorporating vascular impedance analysis and wave intensity analysis. Experimental measurements from healthy animal models will validate the computational framework. The validated model will then quantify how reduced blood supply alters vascular wave propagation, pressure transmission, pulse wave energy, and mechanical interactions between coronary vessels and the myocardium. The project will generate computational tools applicable to blood flow analysis in other organs, integrate findings into biomechanics education, and engage K-12 students and the public on cardiovascular health and biomedical engineering topics. Work is performed at Michigan State University's East Lansing, Michigan campus. The period of performance runs from September 1, 2026, through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $370.7k | 7/20/26 |