Project Grant 2517721
- This $249,894 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports collaborative research at Syracuse University to study the mechanics of tissue boundary formation. The project aims to explain how mechanical forces inside the body help shape developing tissues during early stages of life. By combining expertise from biology and engineering, the research team will investigate how cells move and interact, and how mechanical forces guide their...
- This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This $600,000 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new engineering tools for advancing the understanding of mechanobiology - how biological and mechanical signals interact in the body. The research, titled "BRITE PIVOT: TRANSFORMING MECHANOBIOLOGY - INTEGRATING SPATIAL TRANSCRIPTOMICS, COLLAGEN ARCHITECTURE, AND TISSUE MECHANICS," will focus on studying the effects of endocrine-disrupting chemicals on...
- This federal Project Grant award, valued at $400,000.00, was made by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) to Cornell University. The project, titled "Morphogenesis by Design: An Integrated Mechanobiology Framework for the Sculpting of Architected Biological Tissues", aims to uncover the fundamental mechanistic principles of connective tissue morphogenesis and introduce computational design tools that would instruct the use of robotic...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $240,146 to the University of Alabama to conduct collaborative research on the effects of cellular deformation on the proliferation and motility of single cells. The research aims to engineer specialized microfluidic devices that simulate the tight spaces cells encounter in the human body, enabling the observation of how physical stress impacts cell division, movement, and...
- This $199,982 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) funds research at Wesleyan University to investigate the principles governing the interactions at the interface between different groups of cells. The project aims to understand how cells from different tissues interact and organize themselves when they come into contact, which is crucial for advancing knowledge in areas such as tissue development, wound healing, and cancer...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $250,120 Project Grant to Clemson University to conduct collaborative research on the effect of cellular deformation on the proliferation and motility of single cells. The goal is to engineer specialized microfluidic devices to study how physical stresses experienced by cells in the human body, such as when they move and squeeze through tight spaces, impact their ability to divide and migrate. This research aims to...
- This federal Project Grant award of $489,874 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports a research program at Michigan State University (MSU) to study how epithelial cells respond to prolonged mechanical loads. The central goal of the research is to characterize the "tensioning" phenomenon in epithelial cells as a protective stress response mechanism, and to delineate the underlying mechanosensing processes that mediate this response. This...
- This CAREER award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will provide $314,769 to the University of Delaware to support research advancing the fundamental understanding of how cells and tissue communicate information about their mechanical environment. The project aims to develop new material platforms based on magnetic materials that can dynamically change local tissue stiffness to mimic biological events and measure the resulting mechanobiological...
This $400,000 Project Grant, awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), is funding a collaborative research project at the University of Michigan to study the mechanics of tissue boundary formation. The research aims to explain how mechanical forces inside the body help shape developing tissues during early stages of life, by investigating how cells move, interact, and respond to mechanical cues during tissue formation. The 3-year project will combine expertise from biology and engineering to advance understanding of this fundamental developmental process. In addition to the research, the grant includes educational and outreach efforts to engage students at different levels and inspire them to consider STEM careers. The project seeks to leverage an integrative approach, including stem cell-based models, to overcome challenges in studying this process in mammalian embryos.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.0k | 7/30/25 |