Project Grant 2533972
- The National Science Foundation (CFDA 47.041 - Engineering) awarded a $600,000 CAREER project grant to The Research Foundation for the State University of New York (RF SUNY) to create an integrated platform for understanding neurodegeneration in glaucoma blindness. The 5-year project aims to develop innovative tools to study how glaucoma affects the nerve cells in the eye and explore ways to detect and treat the disease earlier. Key components include: An injectable microbead-based in vivo...
- This $976,308 National Science Foundation project grant funds the University of Miami to develop a novel fundus multiwavelength imaging device for simultaneous multiwavelength imaging of the retinal nerve fiber layer. The goal is to design, construct, and validate a non-contact optical method that can sensitively detect early glaucoma damage through in vivo measurement of retinal spectral reflectance changes. Specifically, the University of Miami will design and construct a new fundus imaging...
- This $1,620,537 federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at Northwestern University to model aqueous humor outflow based on a digital twin of the anterior eye imaged by robotic optical coherence tomography. The research aims to improve understanding of the pathophysiology of glaucoma and enhance the efficacy of minimally invasive glaucoma surgical procedures. The award period runs from September 1, 2025 to August 31, 2028.
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at Emory University to investigate the biomechanical factors contributing to axonal injury in glaucomatous optic neuropathy. The $617,201 award, granted on July 1, 2025, aims to leverage advanced imaging, AI, and engineering tools to directly observe and monitor the deformations of individual optic nerve head axon bundles in response to acute changes in intraocular pressure. The...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $597,232 to the University of Illinois for a research project titled "Intrinsic Signal Optoretinography of Retinal Neurovascular Defects in Neurodegeneration". The goal is to develop a new imaging technique called "intrinsic signal optoretinography" that can detect early signs of Alzheimer's disease in the retina, the light-sensitive tissue at the back of the eye, before...
- This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) provides $387,428 to investigate fundamental mechanisms that drive optic nerve sensitivity to elevated intraocular pressure (IOP), a major risk factor for optic nerve damage in glaucoma. The awardee, The Research Foundation For The State University Of New York, doing business as Upstate Medical Center, will use advanced 3D bioengineering tools, transgenic animal models,...
- The U.S. National Eye Institute awarded a Project Grant of $568,122.00 to Baylor College of Medicine under the Vision Research federal grant program (CFDA 93.867) with a project period from July 1, 2025 to March 31, 2030. The project aims to unequivocally confirm the contribution of the neurovascular unit to glaucoma pathogenesis and identify endothelial cell-specific ligands with potential for neuroprotective therapy. Key objectives include globally mapping all ligands binding to ocular...
- The National Science Foundation (NSF) awarded a $299,999 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Rochester to leverage artificial intelligence velocimetry (AIV) to study cerebrospinal fluid flow in the brain. The goal is to address a critical knowledge gap in understanding how the brain's "cleaning system" functions, particularly in relation to aging, stroke, and Alzheimer's disease. The project will use AIV to infer and...
- This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $661,635 to support research focused on elucidating the molecular changes in the extracellular matrix of the outflow pathway that regulate outflow facility in steroid-induced ocular hypertension and open-angle glaucoma. The research team at SUNY Downstate Health Sciences University will investigate how specific extracellular matrix components induced by steroids...
- This Project Grant awarded by the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $304,998 to Glaive Medical Optics Inc. to develop a novel implantable intraocular lens that can shift the phase of visible light to mitigate vision loss due to age-related macular degeneration. The project aims to create an energy-efficient, small-form factor optical phased array that can electronically adjust visible light frequencies to focus on viable regions...
This Project Grant award, funded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), aims to advance the understanding of biomechanics and fluid dynamics in the aqueous veins of the eye. The $589,056 award, effective from October 1, 2025 to September 30, 2028, will be used by the University of Michigan-Dearborn to study the velocity profiles, wall strains, and flow metrics of the aqueous veins. This research has the potential to enable improved treatments for glaucoma, which affects over 3 million Americans and costs the U.S. $2.86 billion annually. The project will utilize whole-globe perfusion, photoacoustic microscopy, and strain and flow modeling to better understand the quantitative nature of flow in the aqueous veins and how it is impacted by the biomechanical behavior of glaucomatous sclera. The findings from this study could lead to advancements in surgical interventions and decision-making for treating glaucoma.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $589.1k | 8/22/25 |