Project Grant 2612738
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $1,004,927 Project Grant to The Johns Hopkins University from July 1, 2021 to June 30, 2025. The grant supports research titled "Probing Phosphorylation Events in Biological Membranes" under the Biological Sciences program (CFDA 47.074). The goal of the Biological Sciences program is to promote progress in the biological sciences and strengthen the nation's scientific enterprise by increasing...
- The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University $232,938 on February 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to generate critical knowledge on neuronal membrane proteasome-derived peptide signaling in the peripheral nervous system. The research extends prior work on NMP-peptides and their role in peripheral neuron crosstalk and regulation. The award funds proteomics,...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of California, Davis $1,644,245 on June 1, 2026, under the Biological Sciences program (CFDA 47.074) to investigate ion channel dynamics driving proprioceptor maturation. The research examines how changes in sodium channel function and expression contribute to the maturation of proprioceptor electrical signaling during early development as motor skills such as walking are acquired....
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $987,578 project grant to The Johns Hopkins University with a project period from July 1, 2025 to June 30, 2028. The research project seeks to obtain quantitative information about the signaling properties of a member of the receptor tyrosine kinase family in response to different ligands. Highly quantitative biophysical methods will be used to understand how diverse extracellular signals...
- The National Science Foundation Division of Materials Research awarded The Johns Hopkins University $300,000 on April 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to support collaborative research into the structure and function of direct delivery peptides. The project investigates how a newly discovered class of peptides crosses cell membranes directly to deliver cargo molecules with higher efficiency than classical cell penetrating peptides, which typically...
- The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University $131,569 on December 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of microglia in TRPV4-mediated motor neuron degeneration. The research characterizes specific subpopulations of microglia and determines their contributions to transient receptor potential vanilloid 4 (TRPV4)-mediated motor neuron...
- The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University $580,924 on April 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate ionic direct current stimulation as a neuromodulation tool for modulating neural population gain in cortical circuits. The research addresses a precision gap in existing neuromodulation technologies by developing computational models and...
- Federal Project Grant Award Summary The Johns Hopkins University received a $999,993 Project Grant awarded August 1, 2025, through the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The award supports fundamental research investigating the assembly and regulation mechanisms of filamentous signaling platforms—large supramolecular protein structures that coordinate cellular signaling responses and regulate complex...
- The National Institute of Neurological Disorders and Stroke awarded Sanford Burnham Prebys Medical Discovery Institute $670,380 on September 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to determine the stoichiometry of endogenous voltage-gated potassium channels in the brain. The research addresses fundamental gaps in understanding how ion channels are assembled and regulated in neurons. The work will elucidate the...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded $1.8 million to the University of California, San Diego on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to probe connectivity update rules in biological neural networks in vivo. The research will develop an all-optical approach combining two-photon calcium imaging, single-cell holographic optogenetic stimulation, and functional connectivity mapping to measure and experimentally induce...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Johns Hopkins University $1.5 million on September 15, 2026, under the Biological Sciences program (CFDA 47.074) to investigate action potential propagation in unmyelinated axons. The project examines whether sodium and potassium channels concentrate in wider sections of unmyelinated axons and whether membrane shape controls channel insertion and function. Unmyelinated axons lack the myelin insulation of other nerve fibers, yet conduct signals rapidly and reliably through mechanisms not fully understood. The research tests the hypothesis that membrane curvature and local lipid composition create conditions favoring channel placement and activity. The work employs live-cell labeling, electrophysiology, voltage imaging, and electron microscopy to map channel location and function, combined with computer simulations at coarse-grained and atomic levels to model how membrane curvature affects lipid distribution, channel localization, and channel behavior. Results will be incorporated into models of action potential propagation in single axons and small networks. Research is performed in Baltimore, Maryland. The project period runs through August 31, 2031. Beyond basic neuroscience contributions, the work includes scientific training for high school and undergraduate students and outreach events for K-12 audiences. The award aligns with NSF priorities in biotechnology and artificial intelligence.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 7/21/26 |