Project Grant 2602738
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $427,615 to the Regents of the University of Michigan (effective August 1, 2026, through July 31, 2029) under the Biological Sciences program (CFDA 47.074) to support collaborative research on epigenetic silencing mechanisms. The primary deliverable is fundamental scientific research investigating how intrinsically disordered regions (IDRs) of proteins regulate the...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $1.3 million to the University of Pennsylvania under the Biological Sciences program (CFDA 47.074) for the project "Dissecting the HIRA/HIR Chaperone Complex in the Chromatin Landscape." The award, effective July 1, 2026 through June 30, 2029, funds fundamental research into the structural and biochemical mechanisms of the HIRA/HIR (histone regulatory A/histone...
- Federal Project Grant Award Summary MIT received $1,041,774 in funding from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) for a collaborative research project running from August 1, 2025, through July 31, 2029. This project grant supports fundamental research investigating analog information storage in chromatin states, with the goal of understanding how cells encode and maintain their identity through...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $880,000 to the University of Massachusetts Lowell under the Biological Sciences program (CFDA 47.074) for a five-year CAREER grant (June 1, 2026 – May 31, 2031). The project investigates how transgenerational chromatin landscapes regulate cell fate and gene expression in Caenorhabditis elegans, focusing on the mechanisms of epigenetic inheritance—specifically, which histone...
- Federal Grant Award Summary The University of California, San Diego received a $375,000 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The four-year award, active from August 1, 2025 through July 31, 2029, supports collaborative research investigating analog information storage in chromatin states—specifically how cells maintain identity information through gene expression regulation...
- Brandeis University was awarded an $889,060 project grant from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 to July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this model through theoretical modeling combined with...
- This two-year, $1,204,512 National Science Foundation project grant supports research into the robustness and adaptability of the dynamic epigenome through a multiscale approach. Funded under the Biological Sciences program (CFDA 47.074), the award to Brandeis University involves investigating the fundamental rules that guide adaptive epigenetic changes in cells without alterations to the genetic blueprint. The research utilizes high-resolution imaging, microfluidics, and automated culture...
- Brandeis University received a two-year, $299,751 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences to support the project "EAGER: CREATION AND VALIDATION OF A TOOL TO EXAMINE THE MOLECULAR MECHANISM OF REPLICATION FORK REPAIR." The grant's purpose aligns with the Biological Sciences program's goal to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing scientific knowledge...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The project aims to develop new experimental methodology for nuclear magnetic resonance (NMR) spectroscopy to gain quantitative insights into these regulatory mechanisms. The research...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
Grant Award Summary Brandeis University received a $370,052 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), effective August 1, 2026 through July 31, 2029. This collaborative research project investigates how intrinsically disordered regions (IDRs) of heterochromatin-associated proteins facilitate target-binding in living cells, with particular focus on histone H3 lysine 9 methylation (H3K9ME)-binding proteins and their role in establishing stable gene expression states. Using fission yeast (Schizosaccharomyces pombe) as a model system, the research aims to decode fundamental design principles for engineering synthetic proteins capable of targeted gene regulation and cellular reprogramming, thereby advancing biotechnology applications. Beyond core research deliverables, the project incorporates educational and workforce development components designed to translate scientific discoveries into broader impact. These include collaborative demonstrations for middle school students, interactive classroom lectures, and direct laboratory research mentorship for undergraduate students. The initiative bridges biochemistry, physical chemistry, and biology to provide an interdisciplinary training framework, supporting NSF's commitment to strengthening the Nation's scientific enterprise through basic research that enhances understanding of fundamental biological processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $370.1k | 7/15/26 |