Project Grant 2602053
- Federal Project Grant Summary North Carolina State University received a $500,000 Project Grant from the National Science Foundation's Division of Mathematical Sciences under the Mathematical and Physical Sciences (CFDA 47.049) program, effective September 1, 2025 through August 31, 2028. The grant funds the development of a mathematical and computational framework to understand viral-cellular transduction mechanisms in engineered cell therapies. The research integrates experimental studies with...
- Federal Grant Award Summary James Madison University received a $870,218 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), effective September 1, 2026 through August 31, 2030. This Research at Undergraduate Institutions (RUI) award supports basic research investigating obscurin's role as a mechanotransducer—a protein that regulates cellular migration in response to physical environmental...
- This Research Initiation in Undergraduate Institutions (RUI) Project Grant, funded by the National Science Foundation (NSF) Division of Environmental Biology under the Biological Sciences program (CFDA 47.074), supports fundamental research investigating microvesicle-mediated viral transmission using rotavirus as a model system. The $498,069 award, initiated September 1, 2025 and concluding August 31, 2028, is administered through the Research Foundation of the City University of New York...
- Federal Project Grant Award Summary Emory University received a $160,000 Project Grant award from the National Science Foundation's Division of Mathematical Sciences (CFDA 47.049) on September 15, 2025, with a completion date of August 31, 2028. This collaborative research initiative aims to develop and validate a comprehensive multi-physics mathematical model to improve understanding of radiofrequency ablation (RFA) interactions with cardiac tissue. The project integrates theoretical...
- Grant Award Summary North Dakota State University received a $570,477 CAREER Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), effective July 1, 2026 through June 30, 2031. The award supports fundamental research investigating how misplaced DNA and RNA inside cardiomyocytes (heart cells) alter cellular electrical activity and influence innate immune responses. The research will employ...
- Federal Grant Award Summary Washington State University received a $173,787 Project Grant from the National Science Foundation's Division of Mathematical Sciences (CFDA 47.049, Mathematical and Physical Sciences program) effective September 1, 2026, through August 31, 2029. This collaborative research initiative develops multiscale mathematical and computational modeling frameworks to integrate viral infection dynamics across three interconnected biological scales: intracellular processes (viral...
- Federal Project Grant Award Summary The University of Utah received a $594,001 Project Grant from the National Science Foundation's Division of Mathematical Sciences (CFDA 47.049: Mathematical and Physical Sciences) awarded August 15, 2025, with completion targeted for July 31, 2028. The award funds research to advance cardiac digital twins (CDTs)—simulation-based, data-driven models designed to enhance precision medicine approaches for treating cardiovascular diseases, including arrhythmic...
- Federal Project Grant Award Summary The Division of Mathematical Sciences within the National Science Foundation (NSF) awarded $179,147 to the University of Florida under CFDA 47.049 (Mathematical and Physical Sciences) for a collaborative research project on multiscale modeling of viral infections. The project commenced September 1, 2026, with completion targeted for August 31, 2029. This award funds the development of integrated mathematical and computational frameworks that link viral...
- Federal Grant Award Summary Iowa State University of Science and Technology received a $999,745 Project Grant from the National Science Foundation's Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049) awarded September 15, 2025, with completion targeted for August 31, 2028. The award funds development of a multiscale digital twin framework—termed VASCTWIN—designed to predict and control blood vessel growth following cardiac injury by integrating...
- Federal Project Grant Award Summary The University of Michigan received a $300,000 collaborative research project grant awarded September 1, 2025, by the National Science Foundation's Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year award through August 31, 2028, funds the development of next-generation phylodynamic mathematical and computational tools designed to extract epidemiological information from viral genomes....
Federal Grant Award Summary Elon University received a $500,138 Research at Undergraduate Institutions (RUI) Project Grant from the National Science Foundation (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049), effective September 1, 2026 through August 31, 2029. The award funds development and experimental validation of a mathematical model characterizing innate antiviral and inflammatory responses during viral myocarditis. The research integrates computational modeling using coupled ordinary differential equations with wet laboratory experiments to examine interactions between cardiac cells (cardiomyocytes and fibroblasts), recruited immune cells (macrophages), viral pathogens, and signaling mechanisms to identify which cellular communications support cardiac healing versus those that drive pathological inflammation and tissue damage. The project deliverables include validated computational tools and experimentally testable predictions to support development of targeted therapeutic strategies for virus-associated heart inflammation, with potential applications in biotechnology and pharmaceutical development. Additionally, the award supports educational outcomes through hands-on interdisciplinary research training for undergraduate students in mathematics and biology, course development, mentoring activities, conference presentations, and hosting a regional STEM conference for undergraduate researchers. These integrated research and educational components address a significant clinical gap in treating viral myocarditis, for which current therapeutics broadly address infection or inflammation rather than the specific dysregulated processes underlying long-term cardiac damage.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.1k | 7/14/26 |