Project Grant 2505838
- This $200,000 federal Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) aims to improve the understanding of radiofrequency ablation's interactions with heart tissue. The research project combines theoretical modeling, multi-physics and machine learning approaches, and in vivo experiments using human heart tissue. The goal is to develop a detailed multi-physics model to optimize radiofrequency ablation procedures, which are...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $640,562 to Duke University to develop advanced computer models that act as "virtual replicas" of a patient's blood vessels and heart activity. Using data from wearable sensors, the investigators will simulate how blood flows and interacts with vessel walls over time, enabling large-scale in silico testing of medical devices and therapies without...
- This Project Grant award of $172,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by Purdue University and the University of Minnesota-Twin Cities to develop a multiscale computational model that incorporates the nanoscale structure of cardiac intercellular connections, known as ephaptic coupling, and examines its impact on cardiac arrhythmias. The research aims to demonstrate the role of ephaptic coupling as an...
- This $323,230 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a multi-channel radiofrequency and pulsed field energy source generator for cardiac ablation procedures. The award recipient, Sirona Medical Technologies, Inc., is developing a novel catheter device and customizable energy generator to improve the safety and precision of cardiac ablation treatments. Key product features include...
- This National Science Foundation (NSF) Engineering program (CFDA 47.041) project grant award of $650,000 supports research to advance the understanding of blood-clot interactions that may result in stroke for patients with heart rhythm disorders. Specifically, the award will enable the development of a computational model of the left atrium to investigate how the heart's structure changes blood flow patterns and elevates the risk of clot breakup, which can lead to stroke. The research will be...
- Rochester Institute of Technology (RIT) received a $248,480 Project Grant award from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering federal grant program (CFDA 47.041) to develop an interactive, data-enabled scientific computing platform for characterizing and monitoring cardiac tissue ablation. Through leveraging expertise in heat transfer theory, image computing, biomedical modeling and simulation, and...
- This Project Grant award from the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) provides $199,992 to Boston University to develop a high-throughput electrical stimulation screening platform for assessing the long-term effects of cardiac contractility modulation (CCM) devices on engineered human heart tissue. The project will support a postdoctoral scholar co-mentored by researchers at the Food and Drug Administration (FDA) and Boston University to advance...
- This $760,046 federal Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of a computationally-efficient multiscale modeling framework that integrates machine learning and artificial intelligence to predict structural and functional changes in the heart due to disease progression. The project aims to build fundamental understanding of heart disease by combining techniques from...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA Program 93.837 Cardiovascular Diseases Research) provides $601,612 to Northwestern University to develop a novel epicardial high-definition device for detecting and terminating paroxysmal atrial fibrillation (AF). The 4-year project aims to create a fully implantable, organ-conformal system that can rapidly detect AF episodes and deliver painless, low-energy multi-pulse therapy to restore normal heart...
- This $275,000 Project Grant awarded by the National Science Foundation's (NSF) Division of Mathematical Sciences supports the development of novel approaches to solving inverse problems. The goal is to enhance the accuracy and efficiency of computational methods used in critical applications like electrical impedance tomography, inverse scattering, and cryo-electron microscopy. This research has the potential to accelerate breakthroughs in molecular biology and rapid drug development, directly...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) is focused on improving the understanding of radiofrequency ablation's interactions with heart tissue. The $160,000 award to Emory University aims to develop and validate a detailed multi-physics mathematical model of radiofrequency ablation, a medical procedure used to treat conditions like atrial fibrillation. The project will leverage a combination of theory, multi-physics and machine-learning models, as well as experiments using human heart tissue from transplant procedures. The goal is to lead to improved ablation treatments and patient outcomes, with the methodology potentially applicable to other disease types. The award period runs from September 15, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $160.0k | 9/10/25 |