Project Grant 2451660
- The National Science Foundation (NSF) awarded a $450,000 Project Grant under CFDA 47.041 Engineering to North Carolina State University for a 3-year period from March 1, 2025 to February 29, 2028. The project, titled "BIOCENSORS: PARSING OUT THE GENETIC PAYLOAD OF VIRUSES BY DIFFERENTIAL BIORECOGNITION OF CAPSID FEATURES", aims to develop a biosensing technology to detect defective viral particles in gene therapy applications. The project has three key objectives: 1) studying ligand...
- The National Science Foundation (NSF) awarded a $550,000 Project Grant to Colorado State University (CSU) under the CFDA 47.049 Mathematical and Physical Sciences program. The grant supports CSU's Dr. Margarita Herrera-Alonso in exploring the formation of gene-carrying nanoparticles from synthetic macromolecules with complex architectures. The goal is to establish design principles for polymer/gene assemblies that can enhance the stability and therapeutic efficacy of gene therapy delivery...
- The National Science Foundation (NSF) awarded a $300,000 Project Grant under CFDA 47.041 (Engineering) to Northwestern University to research and develop engineered virus-like particles (eVLPs) for drug delivery applications. The objective is to understand how cells produce and assemble eVLPs, which mimic the delivery properties of viruses but cannot replicate or cause infection. The project will also create teaching materials integrating biology, biochemistry, engineering, and computational...
- The National Science Foundation awarded a $568,044 Project Grant to Michigan Technological University from October 1, 2021 to September 30, 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The grant supports collaborative research to predict molecular interactions that can stabilize viral therapies. The Mathematical and Physical Sciences program aims to advance scientific knowledge and enhance understanding of major problems through support of mathematical and physical...
- This $232,771 Project Grant, awarded on September 15, 2025, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The grant aims to develop computational mathematical tools to better understand protein structures and interactions, even across a wide range of mutations. This interdisciplinary research combines mathematical modeling, machine learning, and biology to analyze the complex shapes of proteins, with the goal of enabling...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will fund a collaborative research effort to create computer simulations that study how organic molecules form crystals when mixed with liquids and placed inside nanomaterials. The $312,589 award to North Carolina State University will run from July 1, 2025 to June 30, 2028. The goal is to better understand how the tiny spaces of nanopores affect the nucleation and formation of these crystals,...
- This $200,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by New York University (NYU) School of Medicine. The project aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. Key objectives include: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing temperature-responsive fluorinated hydrogels,...
- This National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) project grant award of $1,500,000 supports research by Dr. Tamar Schlick of New York University and Dr. Alain Laederach of the University of North Carolina at Chapel Hill. The project aims to develop advanced computational tools to predict and control how viral protein synthesis is affected by programmed ribosomal frameshifting (PRF) - the mechanism by which viruses and human cells modify gene expression. Key...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $497,000 in funding to the Rochester Institute of Technology (RIT) to conduct research on the mechanobiology of viral infections. The study aims to explore how mechanical forces, such as changes in tissue stiffness and cyclic strain, impact virus-cell interactions in lung tissue. Specifically, the research will investigate how matrix stiffness and cyclic strain affect viral infection...
- This $180,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) supports research on the development of a broad, model-independent framework for studying complex invasion fronts, which play a key role in the self-organized development of coherent structures in scientific fields like epidemiology, developmental biology, and materials science. The project aims to make theoretical advances and develop computational tools to...
This $500,000 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), supports research to develop a mathematical framework for understanding how porous materials can enhance the efficiency of viral transduction in engineered cell therapies. The award was granted to North Carolina State University (UEI: U3NVH931QJJ3) and will run from September 1, 2025 to August 31, 2028. The key objective of this project is to use computational modeling, artificial intelligence, and experimental studies to quantify how the complex microscale flow physics within porous materials can optimize the delivery of genetic material to cells via viral vectors. This research aims to advance the understanding of viral-cellular transduction, which is a crucial step in making genetically engineered cell therapies more reliable and affordable for treating challenging diseases like cancer, sickle cell disease, HIV, and autoimmune conditions. By integrating the research outcomes into educational initiatives, the project will also help train future scientists and engineers in this important field.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.0k | 8/1/25 |