Project Grant 2533961
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,182,618 to Iowa State University of Science and Technology to develop an advanced "digital twin" technology for personalized cardiovascular care. The goal is to create a rapid, predictive modeling platform that can simulate heart valve disease progression and optimize long-term treatment interventions. The research aims to integrate scientific machine...
- This $455,825 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) was granted to Iowa State University of Science and Technology to develop a personalized digital twin technology for monitoring and understanding cardiovascular aging. The project aims to integrate data from wearable devices, echocardiographic measurements, and advanced cardiovascular modeling to enhance the monitoring and early detection of...
- This $200,000 Project Grant award from the National Science Foundation's Computer and Information Science and Engineering (CFDA 47.070) program will fund the development of advanced computational methods to create high-fidelity, fast-running digital twins of patient hearts and cardiovascular medical devices. The project aims to deliver: 1) novel machine learning algorithms for accurate digital twin geometry reconstruction from 3D medical images, 2) an efficient inverse method to identify in vivo...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $640,562 to Duke University to develop advanced computer models that act as "virtual replicas" of a patient's blood vessels and heart activity. Using data from wearable sensors, the investigators will simulate how blood flows and interacts with vessel walls over time, enabling large-scale in silico testing of medical devices and therapies without...
- This Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 - Engineering) supports a $320,155 research project at Purdue University to investigate the complex flow and transport processes within microvascular networks and their impact on vascular remodeling. The key objectives are to develop a novel computational model integrated with high-resolution imaging data to gain fundamental understanding...
- This National Science Foundation (NSF) Project Grant award under CFDA 47.041 (Engineering) supports the development of a new computational model to predict the complex interactions between ventricular assist devices (VADs) and the beating native heart. The goal is to create a "digital twin" of an experimental mock circulatory loop used for testing VAD safety and efficacy. This $195,291 award, effective August 1, 2024 through July 31, 2026, will result in a lumped parameter model that...
- This $500,000 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the University of Notre Dame's research exploring the differentiation of stem cells into patterned blood vessel networks using hybrid memristor technology. Over a four-year period from October 2022 to September 2026, the University will engineer the first autonomous hybrid memory resistor and cell culture device to control human pluripotent stem cell differentiation into...
- The National Science Foundation (NSF) awarded a $400,000 Project Grant under the Engineering program (CFDA 47.041) to the New Jersey Institute of Technology (NJIT) to advance the understanding of how new blood vessels grow in the body. This 3-year project aims to develop data-driven models that integrate high-fidelity biophysical simulation with high-resolution imaging of real blood vessel networks undergoing growth and adaptation. The research will elucidate the fluid dynamics and biophysics...
- This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $274,811 to Anova Biomedical, Inc. to develop 3D printed personalized vascular grafts using novel elastomeric resins. The key objectives are to: 1) develop and characterize the novel 3D printing resin for producing personalized, elastic, and bioresorbable vascular grafts; 2) demonstrate the ability to 3D print vascular prosthetics using patient CT...
- This federal Project Grant award for $220,000, provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049), aims to deliver a comprehensive mathematical and computational framework for optimizing the design of next-generation stents. Key products and services to be provided under this 3-year award (August 1, 2024 to July 31, 2027) include: Developing a reduced model optimization module for the optimal...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $999,745 to Iowa State University to develop a novel multiscale digital twin framework for predicting and controlling blood vessel growth after cardiac injury. The key products and services to be delivered include: A multiscale modeling framework that integrates molecular signaling dynamics, cellular migration, sprouting patterns, and tissue-level growth and remodeling to predict vascular regeneration. A machine learning architecture for generating 3D vascular network models from 2D sprouting predictions, coupled with elastic tissue deformation. Open-source software packages and a web interface to enable clinical applications, as well as immersive educational tools for students to visualize vascular growth simulations. This project aims to reverse engineer the precise genetic interventions needed to produce desired vascular outcomes, in order to improve regenerative therapies for cardiovascular diseases. The award term runs from Sep 2025 through Aug 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $999.7k | 8/19/25 |