Project Grant 2541292
- This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), provides $357,033 to North Dakota State University (NDSU) from August 15, 2023 to July 31, 2026 to support research on protein manipulation and engineering using an electronic biochemical approach. The project aims to develop a single-molecule manipulation technique to study the dynamics of protein-protein interactions, which is critical for understanding the causes of diseases related to...
- This National Science Foundation (NSF) Engineering (CFDA 47.041) program grant, in the amount of $400,000, supports the development of a tissue-like, converged sensing platform for tracking excitation-contraction dynamics in cardiac organoids. The project aims to: Develop a scalable assembly strategy to fabricate an array of three-dimensional sensor structures using planar semiconducting graphene material, designed to detect both electrical and mechanical stimuli. Evaluate the multifunctional...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is supporting a collaborative research effort focused on developing an intelligent lab-on-chip device to monitor and promote the maturation of stem cell-derived cardiomyocytes. The $192,150 award to the New York Institute of Technology (NYIT) aims to create an integrated system that can non-invasively evaluate cardiomyocyte maturity in real-time and adaptively apply electrical and mechanical...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $418,901.00 to the University of Oklahoma to conduct research aimed at enhancing the understanding of the mechanisms that drive cardiac arrhythmias. The project integrates computational simulations of various physical phenomena with advanced deep-learning techniques to explore how multiple physiological factors can contribute to arrhythmias and their initiation mechanisms. The...
- Federal Grant Award Summary North Dakota State University received a $543,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 8, 2025, through September 7, 2028. This award funds fundamental research investigating the structural basis of cell surface signaling mechanisms in gram-negative bacteria, specifically examining how a site-1 protease (PRC) activates regulated...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $467,202 project grant to the Research Foundation of the City University of New York (RFCUNY) to develop an intelligent lab-on-chip device that can non-invasively monitor the maturation of stem cell-derived cardiomyocytes in real-time and apply adaptive biophysical stimulation to promote full cell maturation. The interdisciplinary research team from RFCUNY, City College of New York, and Rutgers University plans...
- Federal Grant Award Summary The University of New Mexico received a $517,390 Faculty Early Career Development (CAREER) award from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041), effective October 1, 2025 through July 31, 2027. This project grant funds fundamental research to develop engineered adult heart tissue by investigating how multiscale biophysical signals—including material stiffness,...
- This Project Grant award of $172,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by Purdue University and the University of Minnesota-Twin Cities to develop a multiscale computational model that incorporates the nanoscale structure of cardiac intercellular connections, known as ephaptic coupling, and examines its impact on cardiac arrhythmias. The research aims to demonstrate the role of ephaptic coupling as an...
- This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $645,180 to North Carolina State University to conduct a collaborative research project titled "OSIB: A Multi-Omic Evaluation of Innate Immune Responses Across Vertebrate Evolution." The research aims to investigate the evolutionary history and functional diversification of the CD300 gene family, which encodes proteins playing crucial roles in immune function and disease...
CAREER: Electrically Encoded Innate Immune Sensing in Cardiomyocytes North Dakota State University received a $570,477 Project Grant award effective July 1, 2026, through June 30, 2031, from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The award funds fundamental research investigating how electrically active heart cells detect viral infections and cellular damage through electrical signals. The primary research deliverables include scientific findings on how misplaced DNA and RNA within cardiomyocytes alter cellular electrical activity and influence innate immune responses, utilizing patch-clamp electrophysiology, calcium imaging, molecular biology, biochemistry, and computational structural analysis. The project specifically aims to determine how cytosolic nucleic acids affect action potentials and intracellular calcium dynamics, identify responsible ion channels and molecular mechanisms, and evaluate how electrical activity changes regulate innate immune signaling pathways. In addition to research outputs, the award supports an integrated educational program delivering practical STEM training products for high school and undergraduate students. Deliverables include affordable laboratory tools, open-source resources, and solutions designed to address real research needs while benefiting the broader research community. This workforce development component complements the core research mission by engaging students in hands-on scientific training through practical instrument design and resource development aligned with actual laboratory requirements.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $570.5k | 4/27/26 |