This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $645,180 to North Carolina State University (NC State) to conduct collaborative research on the CD300 protein family of immune receptors across vertebrate species. The key objectives are to map the molecular and functional diversification of CD300 genes, proteins, and lipid-binding properties to enhance understanding of how these receptors contribute to immune function and disease susceptibility in mammals, including humans. The multi-omic research approach will also yield new K-12 educational modules on this topic to be made widely available to public school teachers, including the Eastern Band of Cherokee Indian community. This 3-year award, effective August 1, 2024, aims to shed light on the evolutionary history and functional diversification of the CD300 gene family, potentially informing the development of new therapeutic strategies. No federal grant sub-awards are planned under this award.
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