Project Grant 2327147
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is supporting a collaborative research effort focused on developing an intelligent lab-on-chip device to monitor and promote the maturation of stem cell-derived cardiomyocytes. The $192,150 award to the New York Institute of Technology (NYIT) aims to create an integrated system that can non-invasively evaluate cardiomyocyte maturity in real-time and adaptively apply electrical and mechanical...
- This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of...
- The National Science Foundation (NSF) Engineering program awarded a $695,746 CAREER grant to The Washington University's Office of Sponsored Research Services Division to support research aimed at understanding how to grow more mature heart muscle from induced pluripotent stem cells (iPSCs) in the laboratory. The research project will investigate how combining mechanical loading and changes in energy sources can enhance the electrical maturation of iPSC-derived cardiomyocytes to better predict...
- This $100,000 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems supports the development of a 3D human stem cell cardiac model for cardiac electrophysiology medical device safety assessment. Funded under the NSF Engineering program (CFDA 47.041), this award will allow the University of Maryland, College Park to create a novel in vitro model for evaluating the safety and efficacy of cardiac medical devices through January...
- This National Science Foundation (NSF) Engineering (CFDA 47.041) program grant, in the amount of $400,000, supports the development of a tissue-like, converged sensing platform for tracking excitation-contraction dynamics in cardiac organoids. The project aims to: Develop a scalable assembly strategy to fabricate an array of three-dimensional sensor structures using planar semiconducting graphene material, designed to detect both electrical and mechanical stimuli. Evaluate the multifunctional...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $517,390 Project Grant to the University of New Mexico (UNM) for the CAREER: Harnessing Multiscale Biophysical Cues for Engineering Adult Heart Tissue project. The goal of this 2-year research program, starting on October 1, 2025, is to develop a fundamental understanding of how multiscale biophysical signals can be used to improve the structural and functional maturity of engineered heart tissues. The project will...
- This four-year Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems provides $480,000 to support research titled "COLLABORATIVE RESEARCH: RECODE: DIRECTING AND CONTROLLING CARDIAC DIFFERENTIATION THROUGH CELLULAR AND MICROENVIRONMENTAL MANIPULATION AND APPLICATION OF MACHINE-LEARNING." The research is being conducted under the NSF Engineering program (CFDA 47.041) to advance engineering innovation and...
- This $125,805 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies that can identify and separate cells based on changes in the activity of naturally occurring light-emitting molecules like NAD(P)H. The goal is to enable label-free, rapid identification and purification of cell populations, with a focus on stem cells and their functional subsets. The research will create a single cell deposition module to...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) in the amount of $219,999 provides funding to the Regents of the University of Michigan to develop new approaches for precisely guiding stem cells to regenerate damaged tissues. The project, titled "CAREER: Engineering Instructive Niches to Precisely Guide Single Stem Cells," aims to create microenvironments that can direct fundamental stem cell processes like growth, division, and...
- The National Science Foundation awarded a $450,000 Project Grant to the George Washington University under the Engineering federal grant program (CFDA 47.041) to develop scalable heart-on-a-chip platforms. Over a three-year period from April 2022 through March 2025, the University will create automated systems integrating human heart slice culture components with sensor and actuator arrays. This will enable continuous on-chip multiparametric analysis of human cardiac physiology at the cellular...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $467,202 project grant to the Research Foundation of the City University of New York (RFCUNY) to develop an intelligent lab-on-chip device that can non-invasively monitor the maturation of stem cell-derived cardiomyocytes in real-time and apply adaptive biophysical stimulation to promote full cell maturation. The interdisciplinary research team from RFCUNY, City College of New York, and Rutgers University plans to leverage electrical impedance sensing and reinforcement learning techniques to automate the optimization of electrical and mechanical stimulation protocols. This innovative system has the potential to revolutionize the generation of mature cardiomyocytes from pluripotent stem cells for applications in disease modeling, drug screening, tissue engineering, and cardiac therapies. The project will also aim to increase participation and retention of underrepresented students in STEM fields through educational outreach activities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $467.2k | 4/29/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
CM0001469300S | Rutgers The State University Of New Jersey | Project Grant 2327147 | $83.4k | 1/7/25 |