Project Grant 2317111

Award Date 8/15/23
Completion Date 7/31/26
Dollars Obligated $357K
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Fargo, ND 58105, USA
Similar Awards
This National Science Foundation Project Grant of $676,969 supports research at North Dakota State University from May 1, 2023 to April 30, 2028 under the Engineering program (CFDA 47.041). The grant aims to advance fundamental understanding of enzyme interactions with stimuli-responsive nanoparticles at the nanoscale. Specifically, the Principal Investigator will develop histone-mimetic polymerosomes capable of selectively recognizing target enzymes like histone deacetylase, and study how their...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to: Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions. Directly relate the observed domain unfolding of the...
This $500,000 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key objectives are to: (i) synthesize and computationally simulate de novo designed proteins and their respective protein-polymer networks, and (ii) develop techniques for mechanical characterization...
This $616,151 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The research aims to improve the understanding of how tissues form, how embryos develop, and how diseases progress, with potential implications for advancements in tissue engineering and medicine. The 3-year project, set...
This two-year, $200,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research at the Long Beach Research Foundation to develop multi-activity proteins for improved carbohydrate deconstruction. Specifically, the Foundation will produce and test 85 engineered multi-activity proteins containing two catalytic domains each. These proteins aim to increase biomass conversion for alternative fuels and...
This $234,063 National Science Foundation (NSF) project grant, awarded under the NSF Engineering program (CFDA 47.041), seeks to engineer plants to produce enhanced therapeutic proteins and improve protein production performance. The key objectives are to: 1) investigate the glycosylation and functions of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins (GPI-APs) engineered in plant cells; 2) assess the broader applicability and potential applications of GPI-APs in plant cells; and 3)...
This $154,577 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at Duke University to develop machine learning models for predicting protein-nanoparticle interactions. The research aims to characterize the protein "corona" that forms on nanoparticle surfaces and utilize machine learning to forecast how nanoparticle properties influence protein adsorption. This work will advance the understanding of nano-bio...
This $243,319 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research by the University of Florida to characterize protein-polymer conjugates at the atomic level. The goal is to develop a deeper understanding of how polymers can effectively stabilize proteins against denaturation, enabling the design of novel protein-based materials and therapeutics. The research will use NMR spectroscopy to determine the...
This Project Grant award of $1,500,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research to elucidate the design principles for de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key products and services to be delivered include: (1) Development of de novo designed proteins that can be readily transformed into junctions within polymer networks. (2) Investigation of the use of de novo...
The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...

This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), provides $357,033 to North Dakota State University (NDSU) from August 15, 2023 to July 31, 2026 to support research on protein manipulation and engineering using an electronic biochemical approach. The project aims to develop a single-molecule manipulation technique to study the dynamics of protein-protein interactions, which is critical for understanding the causes of diseases related to malfunctioning proteins. Additionally, the project will provide research-based, active-learning opportunities for K-12 students and undergraduates, with a focus on recruiting underrepresented and disadvantaged students, as well as local Native Americans. The research findings may enable the control of enzyme functions by perturbing and stimulating enzyme activities during ligand interactions, which could have significant implications for the field of protein engineering and disease treatment.

Generated 5/14/24, 5:15 AM