Project Grant 2541118
- Federal Project Grant Award Summary The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded $600,000 to the University of Illinois, effective September 1, 2025, through August 31, 2030. This CAREER award supports research focused on developing methods to optically reprogram and replicate neural circuits in zebrafish larvae as a model system for understanding and treating brain disorders. The core deliverable involves demonstrating signal transfer from healthy brains to...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $600,000 CAREER (Faculty Early Career Development) Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective July 1, 2026, through June 30, 2031. The award funds the bioengineering and development of a blood-spinal cord barrier-on-a-chip (BSCB-on-a-chip)—a three-dimensional laboratory...
- Award Summary The University of Pennsylvania received a $637,912 Faculty Early Career Development (CAREER) award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041). Effective July 1, 2026, through June 30, 2031, this project will develop novel bioelectronic devices designed for long-term tissue integration and continuous monitoring of peripheral nerve injuries (PNI). The research team...
- Federal Project Grant Summary The University of Illinois received a $395,787 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), awarded May 1, 2026, with completion targeted for April 30, 2029. The primary deliverable is an innovative laboratory tool that applies precisely controlled mechanical forces to individual neurons using light-driven technology, enabling researchers...
- Federal Grant Award Summary The University of Texas at San Antonio received a $600,000 Faculty Early Career Development (CAREER) award from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041), effective July 1, 2026 through June 30, 2031. The project delivers high-resolution, species-specific computational brain models and digital simulations designed to advance understanding of traumatic brain injury (TBI)...
- Federal Grant Award Summary The University of Chicago received a $715,655 CAREER (Faculty Early Career Development) Project Grant from the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), effective October 1, 2025, through February 28, 2029. This award supports fundamental neuroscience research investigating how multiple brain regions work in concert to enable cognitive flexibility and task switching behavior. The...
- Federal Project Grant Award Summary The University of Illinois received a $600,000 Project Grant award effective October 1, 2025, through September 30, 2028, from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041). This BRITE PIVOT research initiative delivers advanced engineering tools and methodologies that integrate spatial transcriptomics, multiplexed protein profiling, and mechanical characterization...
- Federal Grant Award Summary The University of Illinois received a $597,232 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective August 1, 2025, through July 31, 2028. This award supports the development of intrinsic signal optoretinography (ISOR), a novel noninvasive imaging technique designed to detect early functional biomarkers of Alzheimer's disease in the retina....
- This CAREER award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will provide $314,769 to the University of Delaware to support research advancing the fundamental understanding of how cells and tissue communicate information about their mechanical environment. The project aims to develop new material platforms based on magnetic materials that can dynamically change local tissue stiffness to mimic biological events and measure the resulting mechanobiological...
The University of Illinois received a $599,999 CAREER (Faculty Early Career Development) award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective May 1, 2026 through April 30, 2031. The award funds a five-year research project investigating the role of PIEZO1 protein polymorphisms in traumatic brain injury (TBI) pathology. The primary deliverable is a comprehensive scientific investigation utilizing engineered induced pluripotent stem cells to compare cellular responses to mechanical injury, specifically examining how the E756DEL genetic variant in PIEZO1—a gain-of-function allele that enhances mechanosensitivity—contributes to exacerbated TBI outcomes through altered calcium influx and cellular pathology. In addition to the research deliverables, the award includes a significant education and outreach component designed to engage high school students through hands-on demonstrations and activities that illustrate how genetic factors and trauma collectively influence TBI development. This integrated educational effort aligns with NSF Engineering program priorities emphasizing both technical innovation and workforce development. The project will produce cellular models, comparative analysis data, and educational materials addressing the intersection of genetics, biomechanics, and neurological injury.Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $600.0k | 4/30/26 |