Project Grant 2403731
- This National Science Foundation Project Grant, awarded under the Engineering program (CFDA 47.041), provides $206,132 to Louisiana State University to conduct fundamental research on the high strain rate mechanics of the human brain. The research aims to develop advanced computational models and experimental techniques to better understand the complex mechanical behavior of the living human brain under extreme loading conditions, such as those encountered during traumatic brain injuries. The...
- The National Science Foundation (NSF) awarded The Johns Hopkins University a 3-year, $274,297 Project Grant under the Engineering program (CFDA 47.041) to conduct collaborative research on the extreme mechanics of the human brain. The research aims to generate insights into how the living human brain responds to large and rapid loading, which is critical for developing models to predict traumatic brain injury and designing safer protective equipment. The project will combine high-rate mechanical...
- The National Science Foundation awarded a $118,212 Project Grant to the University of Delaware under the Integrative Activities (IA) program (CFDA 47.083) to conduct fundamental research on the extreme mechanics of the human brain. The research combines high-rate mechanical testing, analytical and computational modeling, and machine learning to generate insights into how the living human brain responds to large and rapid loading. This work will contribute to the fields of tissue mechanics,...
- This three-year, $598,468 project grant from the National Science Foundation's Engineering Directorate (CFDA 47.041) will support research at Rowan University to improve understanding of astrocyte mechanobiology following central nervous system injury. The grantee will use magnetically active hydrogels to interrogate how dynamically changing tissue stiffness affects astrocyte contribution to glial scar formation after spinal cord injury. Experiments will characterize mechanical property...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award provides $274,855 to Mito-Biotherapeutics, Inc. to develop a novel fusion protein construct (NFP) that can cross the blood-brain barrier and deliver a therapeutic payload to repair mitochondrial DNA damage in neurons following traumatic brain injury (TBI). The project aims to attenuate neurological damage and prevent the progression of TBI to neurodegenerative diseases like...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,499,886 Project Grant to Astrocyte Pharmaceuticals Inc. under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports preclinical efficacy and safety evaluation of Astrocyte's oral drug candidate AST-004 for the treatment of moderate traumatic brain injury (TBI). The project aims to develop an oral formulation of AST-004, building on prior...
- This Project Grant award from the National Science Foundation's Computer and Information Science and Engineering (CISE) program, CFDA 47.070, provides $225,000.00 to the Regents of the University of California at Riverside to conduct research on how astrocytes, a type of brain cell, contribute to neural dynamics and information processing in the brain. The project combines computational modeling and experiments to study how astrocytes modulate neuronal activity and communication, with the goal...
- The University of Illinois, doing business as The Board of Trustees of the University of Illinois, received a $457,049 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders. The grant, awarded on Sep 15, 2023, will fund research to apply human in vitro models to understand the link between traumatic brain injury (TBI) and tau pathology in Alzheimer's disease and...
- This Project Grant award of $559,820 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by the University of South Carolina to characterize the biomechanical response of the human brain during traumatic brain injury (TBI). The research aims to integrate dynamic MRI and sonomicrometry techniques to measure brain deformation at both low and high...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation across a range of force and strain rate regimes. The goal is to gain fundamental knowledge about how astrocytes can be activated, permanently or reversibly, in response to low, repeated forces, which could inform the design of protective gear, monitoring devices for TBI, and improve public understanding of forces that could lead to permanent brain damage. The award will also support outreach efforts to provide female high school students, particularly those from underrepresented groups in STEM, with biomechanics and mechanobiology research opportunities and mentoring. This research has the potential to transform the understanding of how astrocytes sense and respond to force, advancing knowledge of how brain injury occurs and leads to long-term cognitive deficits.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $705.8k | 7/10/24 |