Project Grant 2527188
- This Project Grant award of $400,000 from the National Science Foundation's Engineering program (CFDA 47.041) supports a collaborative research effort to study the mechanics of tissue boundary formation during early stages of development. The research aims to explain how mechanical forces inside the body help shape developing tissues and organs. By combining expertise from biology and engineering, the project will advance scientific understanding of tissue formation and potentially lead to new...
- This Project Grant award of $629,999.00 from the National Science Foundation's Engineering program (CFDA 47.041) will support a CAREER project at Washington University in St. Louis to investigate how dynamic stiffness of the microenvironment of ovarian follicles influences their growth characteristics. The goal is to develop a bioelectronic material platform that can modulate the stiffness of the follicle microenvironment to study the relationship between mechanical stimuli and follicle...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This $995,498 National Science Foundation project grant supports research at the University of California, Los Angeles to advance knowledge of cellular mechanobiology and translate findings for sustainable protein production. Funded through the NSF's Engineering program (CFDA 47.041), the research aims to understand how cells sense and respond to mechanical stimuli by building a systems-level understanding of the "mechanome." Specific goals include investigating predicted mechanical...
- The National Science Foundation's Engineering program (CFDA 47.041) awarded a $225,281 CAREER grant to Tulane University to explore the research and development of sex-based human cell culture methods and engineered tissue models. The project will deliver female and male culture medium formulations with defined sex hormone compositions, as well as engineered tissue models for studying sex differences in various organs. This research aims to facilitate the development of sex-based medicines...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to quantify the mechanical forces within living cells and determine how changes in these forces impact the production and secretion of proteins that shape the cellular environment. The total funding amount is $297,984.00 and the award period is from February 1, 2025 to January 31, 2028. The research team at the University of Texas Health Science Center at Houston aims to develop...
- This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant award of $342,318 supports research at the University of Wisconsin - Madison to develop a novel theoretical and computational framework for modeling the mechanical deformation and interactions of biomembranes with transport and electrochemical processes. The 3-year research project, starting on Sep 1, 2024, aims to create an open-source computational tool to model key biomembrane phenomena like endocytosis,...
- This $285,570 CAREER award from the National Science Foundation's Engineering program (CFDA 47.041) supports a research project at the University of Vermont that investigates living tissues as new types of adaptive materials. The project will explore how cellular adaptability, such as epithelial-mesenchymal transitions and coordinated cell movements, influences the mechanical behavior of tissues at larger scales. This research is expected to advance the understanding of biological processes...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $249,894.00 to Syracuse University to study the mechanics of tissue boundary formation through a collaborative research project. The research aims to explain how mechanical forces inside the body shape developing tissues during early stages of life by investigating cell movement, interaction, and the role of mechanical forces in guiding tissue formation. The project combines expertise...
- This $2,249,999 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will fund research to develop new sensing technologies for use in 3D cell cultures using cells from the nervous system. The objective is to create manufacturable 3D mammalian cell culture systems focusing on neural organoids with incorporated sensing technologies. Key research goals include: (1) building and testing conformal microelectrode arrays to interrogate neural organoids...
This $600,000 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop new engineering tools to better understand the interactions between biological and mechanical signals in the body. The research focuses on investigating how exposure to endocrine-disrupting chemicals may affect fertility and pregnancy, by integrating spatial omics, protein profiling, and mechanical/imaging data. Key products to be developed include a multi-scale framework for studying mechanobiology, mapping relationships between molecular signals, tissue microstructure, and mechanical properties. The research, conducted by the University of Illinois, could yield insights into inflammation and fibrosis in other organs like the lung, kidney, and liver. The award period runs from October 1, 2025 to September 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $600.0k | 8/3/25 |