Project Grant 2513952
- This three-year, $658,002 National Science Foundation Engineering project grant funds research at Florida Atlantic University investigating changes in cerebral and retinal blood flow responses as a potential early diagnosis mechanism for Alzheimer's disease. The goal is to establish a viable, cost-effective early detection strategy through eye imaging procedures and new optical technologies measuring eye and brain blood flow changes associated with Alzheimer's. Machine learning tools will...
- This Project Grant award of $583,679 was provided by the National Science Foundation (NSF) Engineering program (CFDA 47.041) to the University of California, Davis (UC Davis). The grant aims to develop an innovative "Correlative, Simultaneous Microscopy of Optical Signatures (COSMOS)" system capable of simultaneously imaging multiple aspects of the brain, including fluorescence, second harmonic generation, and quantitative phase signals. This advanced microscopy system will enable...
- This federal Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to create innovative tools to understand neurodegeneration in glaucoma blindness. The $600,000 award, with a project period from Jul 1, 2025 to Jun 30, 2030, supports the development of an integrated platform that combines bioengineering tools and neurobiological studies. Key components include: (1) an injectable microbead-based in vivo flow occlusion model to replicate...
- The University of Illinois has been awarded a $1,870,822 Project Grant from the National Institute on Aging's Aging Research program (CFDA 93.866) to develop new super-resolution fluorescence microscopy techniques. The goal is to achieve ultra-high resolution imaging of native amyloid-alpha receptors (AMPARs) in brain slices to study synaptic plasticity in both healthy and tauopathy conditions. The research will utilize multi-color imaging and digital image reconstruction methods to isolate...
- The National Science Foundation (NSF) awarded a $500,000 Project Grant under the CFDA 47.041 Engineering program to the University of Illinois, located in Urbana, IL. This 5-year CAREER award (March 1, 2025 - February 28, 2030) seeks to develop a new "Super-Resolution PAUL (SPAUL)" imaging system that combines ultrasound and photoacoustic imaging techniques. The goal is to capture high-resolution, real-time images of cerebral blood flow, volume, and oxygenation in animal models,...
- This Project Grant award of $500,000 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to support the development of an in vivo imaging platform called the VasoVue Lab. The objective is to enable rapid, non-invasive assessment of cerebrovascular dysfunction, which is known to be impaired in Alzheimer's disease (AD). The proposed solution will use laser speckle contrast imaging to monitor blood flow changes in the retina and brain...
- This $325,000 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) to the Texas A&M Engineering Experiment Station (Tees) aims to develop 3D-integrated micro-photometer chips that enable minimally invasive, long-term stable, and high-quality fluorescence recording in deep brain regions. The research will elucidate the effects of beam collimation, compact chip size, and mechanical flexibility of implantable optoelectronic probes on the quality of in...
- This $375,840 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of advanced machine learning models to enable accurate and early prediction of Alzheimer's disease and related dementias (ADRD). The project, led by the University of Virginia, will leverage novel natural language processing techniques to automatically extract personal risk factors for ADRD from electronic health...
- This Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) provides $285,122 to the University of Louisiana at Lafayette (UL Lafayette) to conduct basic research in artificial intelligence (AI) for cost-effective image analysis. The two-year project, running from February 2026 to January 2028, will support a faculty fellowship and graduate student training to develop novel AI frameworks that can adapt hospital-grade medical images to...
- This $976,308 National Science Foundation project grant funds the University of Miami to develop a novel fundus multiwavelength imaging device for simultaneous multiwavelength imaging of the retinal nerve fiber layer. The goal is to design, construct, and validate a non-contact optical method that can sensitively detect early glaucoma damage through in vivo measurement of retinal spectral reflectance changes. Specifically, the University of Miami will design and construct a new fundus imaging...
This Project Grant award from the National Science Foundation (CFDA 47.041 - Engineering) provides $597,232.00 to the University of Illinois to develop a new imaging technique called "intrinsic signal optoretinography" for detecting early functional biomarkers of Alzheimer's disease in the retina. The research aims to establish this noninvasive, quantitative method for measuring changes in the retina that could indicate neurodegeneration in the brain before structural damage is visible. The project will study three major neurovascular biomarkers in mouse models and leverage a custom-built, multi-modal optical coherence tomography system. The research supports early detection of Alzheimer's disease and provides training opportunities for students in science and engineering. The award period runs from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $597.2k | 7/21/25 |