Project Grant 2540253
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- Federal Grant Award Summary The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded the University of Florida $2.999 million on January 1, 2026, for a three-year project (through December 31, 2028) to develop advanced biosensors using living cell crystals for environmental monitoring, healthcare diagnostics, and national security applications. The project addresses critical limitations in current pathogen and toxin detection capabilities by leveraging genetically...
- This $763,328 CAREER award from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) supports research on designing dynamic protein structures with enhanced functionality. Awarded to the Research Foundation of The City University of New York (RFCUNY), operating as the Advanced Science Research Center, on June 15, 2026, with completion targeted for May 31, 2031, the project delivers fundamental research...
- Federal Project Grant Award Summary The Trustees of Boston University received a $885,642 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences (Biological Sciences Program, CFDA 47.074) effective September 1, 2025, through August 31, 2028. The award supports research to characterize signal propagation and control within gene regulatory networks using optogenetic techniques. The primary deliverables include foundational scientific knowledge regarding...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $350,000 under the Biological Sciences program (CFDA 47.074) to Trustees of Tufts College for the TOOLS4CELLS project, effective August 1, 2025, through July 31, 2026. This Project Grant supports the development of turn-on biosensors (TOBS)—a novel measurement technology enabling real-time detection of endogenous biomolecules in live cells. The primary deliverable is the...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $629,896 Project Grant to the University of Wisconsin-Madison on February 15, 2021 with a completion date of January 31, 2026. The grant supports research under the Biological Sciences program (CFDA 47.074) to advance understanding of heterogeneous decision-making in individual microbes and populations through synthetic approaches. As the official program description indicates, the Biological Sciences...
- The University of Florida was awarded a $172,749 Project Grant from the National Science Foundation Division of Integrative Organismal Systems under the Biological Sciences federal grant program (CFDA 47.074) to conduct research on the cell biology of cnidarian-dinoflagellate symbiosis from August 15, 2021 to July 31, 2024. As part of this award, the University will investigate signaling, regulation and host response pathways involved in the symbiotic relationship between certain marine...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...
- This three-year, $992,280 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research into "Synthetic P-Bodies: Coupling Gene Expression and Ribonucleoprotein Granules in Synthetic Cell Vesicles for Sensing and Response" being conducted by The University of New Mexico from August 2021 through July 2024. The University will design and test genetic circuits, optimize lyophilization protocols, and develop cell-free protein expression...
The National Science Foundation's Division of Molecular and Cellular Biosciences awarded the University of Florida $692,207 under the Biological Sciences program (CFDA 47.074) on May 15, 2026, for a project addressing synthetic cell signal transduction through protein engineering. The award funds research to design and synthesize recombinant globular protein vesicles with controlled membrane asymmetry and integrated signal transduction capabilities. Key deliverables include the development of modular bolaamphiphilic fusion proteins that self-assemble into asymmetric vesicle membranes with defined protein orientation, enabling directional sensing and programmable signal processing that mimics natural cellular functions. Research outcomes will advance biotechnology through novel biosensing applications and bio-inspired materials development, with performance expected through April 30, 2029. In addition to advancing fundamental scientific understanding of protein-based synthetic systems, this project includes substantial workforce development components. The award supports interdisciplinary training for undergraduate and graduate students in protein engineering, biomaterials, and synthetic biology, while incorporating outreach activities to K-12 students through hands-on modules. These educational initiatives aim to broaden participation in STEM disciplines and strengthen the future biotechnology workforce, thereby supporting national competitiveness in an area of strategic importance to health, economics, and innovation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $692.2k | 5/4/26 |