Project Grant 2529591
Award Date
1/15/25
Completion Date
8/31/26
Dollars Obligated
$542K
Federal Agency
Division of Molecular and Cellular Biosciences
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Worcester, MA 01655, USA
Similar Awards
The University of Iowa received a $470,000 National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) to conduct collaborative research on the effect of transcription factor binding on UV lesion accumulation in the human genome. The research aims to determine whether transcription factor binding enhances the frequency of DNA damage or impairs DNA repair, leading to increased mutation rates in those genomic regions. The project will develop innovative...
This $588,426 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) will fund a project to resolve the mechanisms by which transcription factors (TFs) efficiently locate their specific target DNA binding sites within the crowded nucleus of human and mouse cells. The project will employ an advanced microscopy technique that enables precise 3D tracking of TF movements and interactions with DNA at unprecedented spatial and...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) totaling $329,172 funds a collaborative research project to investigate how the SMC5/6 protein complex manages branched DNA structures during DNA repair processes. The research teams at North Carolina State University will use complementary biochemical and high-speed atomic force microscopy (HS-AFM) methodologies to examine how SMC5/6 recognizes and processes key DNA repair...
This $246,424 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support research at the University of California, Santa Barbara (UCSB) to better understand how human cells control the initiation and early steps of recombination at DNA double-strand breaks. The research aims to leverage recent discoveries about DNA crosslink-stimulated recombination to analyze key mechanisms regulating the recombination process. The project has...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 provides funding for a postdoctoral research fellowship from July 1, 2024 to June 30, 2027. The fellowship will support research and training to investigate the rules governing interactions between genomes, environment, and phenotypes, with a focus on understanding how repetitive DNA sequences, particularly a satellite repeat on the X chromosome of Drosophila melanogaster,...
This $150,000 Project Grant was awarded on March 15, 2025 by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The project aims to enhance the natural DNA repair mechanisms of mitochondria, which are essential for cellular energy production but also a significant source of damaging reactive oxygen species. The research will focus on re-engineering mitochondrial targeting signals of key DNA repair enzymes...
This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will support a collaborative research project between research teams to investigate how the SMC5/6 protein complex manages various branched DNA structures that form during DNA repair processes. The objective is to gain a high-resolution understanding of the structure and function of SMC5/6 to advance knowledge of how cells resolve DNA repair intermediates and maintain genome...
The University of California, San Diego received a $300,000 Project Grant award from the National Science Foundation on February 1, 2021 to develop a high-throughput in vivo method for measuring transcription factor-DNA interactions. The grant supports research under the NSF's Biological Sciences program (CFDA 47.074) through January 31, 2023. The Biological Sciences program aims to advance the fundamental biological sciences and enhance understanding of major problems through basic research....
This $2,285,694 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Tufts University to study the relationship between DNA replication and tandem repeat instability. The grantee will combine genetic assays and single-cell live microscopy analysis in a model system to understand how repeat length changes during replication. This dual approach will examine how a repeat's length, propensity to form DNA structures, and orientation...