Project Grant 2324615
- This federal Project Grant award, valued at $541,574.00 and awarded on January 15, 2025, is funded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program. The project, titled "COLLABORATIVE RESEARCH: NSF/MCB-BSF: THE EFFECT OF TRANSCRIPTION FACTOR BINDING ON UV LESION ACCUMULATION", aims to determine whether transcription factor binding to DNA makes it more susceptible to damage or impedes DNA repair, leading to increased genomic...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $350,000 to the University of Iowa to support research on the mechanisms involved in the propagation of chromosome fragments in the germline. The 3-year project aims to investigate how DNA breaks that occur during the formation of egg and sperm cells are stabilized and passed on to the next generation. The research will be conducted using the model organism C. elegans and will...
- This $363,800 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by The Johns Hopkins University investigating how supercoiled DNA impacts transcription, a core process of life that converts genetic information into RNA. The research will: Characterize how supercoiling affects transcription kinetics and correlation using in vitro single-molecule imaging of purified proteins and DNA constructs. Determine how chromosomal...
- The University of California, San Diego received a $300,000 Project Grant award from the National Science Foundation on February 1, 2021 to develop a high-throughput in vivo method for measuring transcription factor-DNA interactions. The grant supports research under the NSF's Biological Sciences program (CFDA 47.074) through January 31, 2023. The Biological Sciences program aims to advance the fundamental biological sciences and enhance understanding of major problems through basic research....
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $495,594.00 to the University of California, Santa Barbara to conduct research on the mechanisms underlying DNA double-strand break repair through homologous recombination. The objectives of this 5-year project are to 1) define the steps in recombination altered by DNA interstrand crosslinks, 2) explore how the DNA repair regulatory kinase ATR is activated during double-strand break...
- The National Science Foundation (NSF) awarded a $900,000 Project Grant under the Biological Sciences (CFDA 47.074) Federal Grant Program to the University of Iowa for a research project titled "Genetic Basis and Evolution of the Transcriptional Response to Oxidative Stress in Diverse Yeasts". The project will investigate how the genetic networks that control the response to oxidative stress, such as exposure to hydrogen peroxide, have evolved across diverse yeast species, including...
- This Project Grant award of $550,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Iowa State University to investigate how different histone writer enzymes coordinate to regulate gene expression and chromatin structure. The project will explore how the histone modifications H3K9me2, H3S10ph, and H4K16ac work together to fine-tune gene expression levels by controlling chromatin accessibility. Experiments will utilize Drosophila larval...
- This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $910,000 over 4 years to Weill Medical College of Cornell University to conduct research on the regulation of DNA repair mechanisms and transcription at telomeres. The research aims to improve understanding of how genetic information is protected at chromosome ends, which is critical for cell and organism health. The...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- This $930,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) is focused on advancing the understanding of transcription fidelity mechanisms in eukaryotic RNA polymerases. The project at the University of Alabama at Birmingham (UAB) will employ transient state kinetic approaches to quantify the differences in transcription and error correction mechanisms across the three eukaryotic RNA polymerases (I, II, and III). This research aims...
The University of Iowa received a $470,000 National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) to conduct collaborative research on the effect of transcription factor binding on UV lesion accumulation in the human genome. The research aims to determine whether transcription factor binding enhances the frequency of DNA damage or impairs DNA repair, leading to increased mutation rates in those genomic regions. The project will develop innovative experimental and computational methods to quantify DNA damage and repair at transcription factor binding sites. The research findings are expected to significantly advance the understanding of the molecular mechanisms underlying the non-uniform distribution of genetic variation across the human genome. In addition to the scientific research, the project includes broader impact activities such as workshops for high school students and academic professionals to engage the next generation of scientists.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $470.0k | 7/28/23 |