Project Grant 2523526
- This Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), will support research to investigate how the three-dimensional organization of the human genome controls gene expression and cell identity in the brain. The $300,000 award, spanning August 2025 to July 2027, will fund the development of new AI-powered tools to reconstruct 3D chromosome structure from single-cell experiments and simulate how changes in genome structure affect...
- This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- This two-year, $1,204,512 National Science Foundation project grant supports research into the robustness and adaptability of the dynamic epigenome through a multiscale approach. Funded under the Biological Sciences program (CFDA 47.074), the award to Brandeis University involves investigating the fundamental rules that guide adaptive epigenetic changes in cells without alterations to the genetic blueprint. The research utilizes high-resolution imaging, microfluidics, and automated culture...
- This Project Grant, awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074), provides $900,000 in funding to The Regents of the University of Colorado from February 1, 2025 to January 31, 2028. The project focuses on uncovering the molecular mechanisms by which the DNA methyltransferase 1 (DNMT1) enzyme regulates gene silencing and the inheritance of distinct cell identities. The research will utilize structural biology, biochemistry, and cell biology methods to...
- This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...
- This Project Grant award of $550,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Iowa State University to investigate how different histone writer enzymes coordinate to regulate gene expression and chromatin structure. The project will explore how the histone modifications H3K9me2, H3S10ph, and H4K16ac work together to fine-tune gene expression levels by controlling chromatin accessibility. Experiments will utilize Drosophila larval...
- This $360,044 award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program supports a collaborative research project at Indiana University, Bloomington. The project aims to uncover fundamental principles of evolution by studying the relationship between an individual's choice of environment and the developmental processes that are shaped by that environment, using fruit flies as a model organism. The research will integrate theory and experiments across...
- This $1,000,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research led by the University of Florida (UF) to investigate the origins and evolution of neural systems in ctenophores (comb jellies). The 5-year project aims to uncover novel signaling molecules and neural specification mechanisms in these enigmatic marine organisms, which are the sister group to all other animals. By leveraging advanced multi-omics,...
- This National Science Foundation Project Grant of $138,000 supported postdoctoral research fellowship at Indiana University from June 1, 2022 to May 31, 2024 under the Biological Sciences program (CFDA 47.074). The fellowship focused on investigating the cis-regulatory basis of developmental plasticity and growth in the evolution of beetle horns through three main research objectives: 1) characterizing the roles of chromatin accessibility and regulatory element sequences in beetle horn...
This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Indiana University to investigate the role of epigenetic mechanisms in regulating gene expression programs during the development of the cerebral cortex in mammals. The project aims to elucidate how specific histone modifications influence neurogenesis and cell fate specification, with the goal of enhancing fundamental understanding of mammalian, including human, cortical development. Additionally, the award includes an educational component to engage and train high school students, teachers, and undergraduate/graduate students in the fields of genomics, epigenetics, and neurodevelopment. The grant period runs from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 7/29/25 |