This Project Grant award of $550,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Iowa State University to investigate how different histone writer enzymes coordinate to regulate gene expression and chromatin structure.
The project will explore how the histone modifications H3K9me2, H3S10ph, and H4K16ac work together to fine-tune gene expression levels by controlling chromatin accessibility. Experiments will utilize Drosophila larval salivary glands to study the interplay between the histone writer enzymes JIL-1, Su(var)3-9, and MOF, and how they may directly regulate each other through post-translational modifications. The research aims to provide new insights into the dynamic "rheostat" regulation of gene expression. Some of the experimental work will be incorporated into undergraduate research projects to provide hands-on training. The project period runs from May 1, 2024 to April 30, 2027.
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