Project Grant 2225624
- Federal Grant Award Summary The National Science Foundation's Directorate for Engineering (CFDA 47.041) awarded the University of California Santa Cruz $1,958,603 in Project Grant funding (Award Date: August 1, 2025; Project Period: August 1, 2025–July 31, 2029) to develop an experimental and computational framework for exploring the learning and computational capabilities of human brain organoids derived from induced pluripotent stem cells (iPSCs). The primary deliverables include the design...
- The National Science Foundation (NSF) Engineering Directorate awarded a $564,510 Project Grant to the University of Massachusetts (UMass) to develop an engineered neural organoid system with improved brain regionalization and integrated mesh electrodes for enhanced monitoring and stimulation capabilities. The key objectives of this 3-year grant project are to: 1) Assemble regionalized neural organoids that enable thalamus-subpallium-cortex projections by stacking sliced organoids, 2) Innervate...
- The National Science Foundation awarded a $587,853 Project Grant to The Research Foundation For The State University Of New York to fund research into the mechanics of cortical folding patterns in the developing human brain. The three-year award runs from July 1, 2021 to June 30, 2024 under the NSF Engineering program (CFDA 47.041). The grantee and sub-awardee, Boston Children's Hospital, will conduct research to improve understanding of how patterns in the cerebral cortex form during human...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded The Johns Hopkins University a $2.0 million Project Grant effective August 1, 2025 through July 31, 2029 to advance organoid intelligence (OI) research through the "Bringing Reward to Embodied Organoid Intelligence" initiative. The project will develop lab-grown brain tissues engineered into three-tier brain assembloids incorporating cortical, dopaminergic, and striatal...
- This $299,844 Project Grant awarded by the National Science Foundation (NSF) under the STEM Education program (CFDA 47.076) supports the development of a microfluidic cortical organoid-vasculature platform at North Carolina Agricultural and Technical State University (NC A&T). The project aims to establish a new framework for "organoid-vasculature intelligence" by integrating the organoid platform with microelectrode array recording/stimulation and machine learning models. The...
- This $400,000 Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) supports the development of a new hardware system designed to meet the increasing computational demands for sophisticated multi-scale brain models. The project aims to bridge the timescales between cognitive phenomena and the underlying neuronal processes, enabling more detailed computer simulations to advance fundamental neuroscience research and the translation of biological...
- The University of California, San Diego will receive $400,000 from the National Science Foundation under the Engineering (CFDA 47.041) federal grant program to research the mechanisms of microgravity accelerated aging on human brain organoids from October 1, 2021 to September 30, 2024. Through this three-year Project Grant, UCSD researchers will study how microgravity exposure impacts the aging process in miniaturized human brain tissues grown in a laboratory, with the goal of furthering...
- Federal Project Grant Award Summary The University of California at Riverside received a $447,488 Project Grant award from the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), effective October 1, 2025, with completion by December 31, 2026. This CAREER award, funded under the American Rescue Plan Act of 2021, supports mechanistic research on cilium proteins involved in cell signaling during brain development. The...
- The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $135,000 Project Grant to the University of Central Florida (UCF) for the project "COLLABORATIVE RESEARCH: EAGER: 3D BIOPRINTED ORGANOIDS FOR STUDYING THE MECHANISM OF CEREBROVASCULAR AGING". This award supports the development of 3D bioprinted cerebrovascular organoids derived from human induced pluripotent stem cells to study the impact of cellular senescence...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a Project Grant of $1,180,687 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), with an award date of August 1, 2025, and completion date of July 31, 2033. This eight-year research initiative focuses on investigating the developmental transition of neural stem cell (NSC)...
This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise in developmental biology, soft materials engineering, and bioinformatics to engineer the spatial patterning of morphogens within a responsive hydrogel platform. This will enable examination of gene regulatory networks underlying signaling interactions during cortical arealization using single-cell and spatial transcriptomics. A sub-award of $250,000 will support complementary analyses of large datasets from these techniques by researchers at the University of Pennsylvania. Their work will aim to uncover novel gene regulatory networks governing cortical development. Outreach and education activities engaged in by the grantees are expected to broaden participation in science, technology, engineering and math fields. Overall, the grant aims to advance fundamental understanding of human brain development and disease through improved organoid models.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 11/17/22 | ||
| Not listed | $1.5m | 8/1/22 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
202218354S | The Trustees Of The University Of Pennsylvania | Project Grant 2225624 | $64.4k | 1/27/26 | |
202218353S | The Trustees Of The University Of Pennsylvania | Project Grant 2225624 | $64.4k | 3/4/25 |