Project Grant 2517807
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $380,000 to Northeastern University to develop a new generation of computational models for studying eukaryotic cell motility. The research aims to better understand how cells move through complex tissues, which is critical for both healthy developmental processes and the spread of cancer. The project will involve a collaborative effort between...
- This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...
- The National Science Foundation (NSF) awarded a Project Grant of $419,168 under the Biological Sciences (CFDA 47.074) federal grant program to Duke University. This collaborative research project will study the multiscale mechanics of septin assembly and curvature sensing in biological cells. The research aims to determine how cells can sense micron-scale geometry using nanometer-scale septin proteins. The project will examine septin assembly across three scales - individual septin molecules,...
- This Project Grant award of $891,897 from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program supports a collaborative research effort to study the multiscale mechanics of septin assembly and curvature sensing in biological cells. The research, conducted by the University of North Carolina at Chapel Hill (UNC-CH), aims to determine how cells can sense micron-scale geometry using nanometer-scale septin proteins. Key objectives include investigating...
- This National Science Foundation Project Grant of $492,743 will fund research into the impacts of intracellular and extracellular hydraulic environments on mammalian cell migration in confined spaces. Awarded on October 15, 2022 under the Engineering program (CFDA 47.041), the funding will support mathematical modeling to decipher the coupled effects of fluid interaction with cellular structures on cell behavior in confined migration. The awardee, the Research Foundation for the State University...
- This National Science Foundation Project Grant of $419,750 will fund research at Washington University in St. Louis from August 1, 2022 to July 31, 2025 to study how living cells move across dissimilar physical environments and retain mechanical memories of prior environments. Specifically, the award will integrate experiments and computational modeling to examine how forces generated by cells modify their surroundings in two mechanically different environments during migration. This will reveal...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Northeastern University a $100,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to support research on "The Biophysics of Collective Cell Locomotion" from December 15, 2021 through December 31, 2023. Through this funding, Northeastern University researchers in Boston, MA will investigate the major problem of understanding the biological sciences by examining the...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This $1,735,683 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to determine the three-dimensional structure of the Z ring, a critical component in bacterial cell division. The project aims to use advanced nuclear magnetic resonance spectroscopy methods to study the structure, dynamics, and potential drug binding sites of the Z ring, which could inform the development of new antibiotics. The research will be conducted by...
- This Project Grant award, provided by the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research between Indiana University Indianapolis and Purdue University to develop a novel multi-scale 3D mathematical model to simulate cell migration. The $200,000 award will enable the researchers to integrate experimentally measured intracellular tension data into the model to better understand how external environmental factors, such as...
This Project Grant award for $1,132,274 from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program will support research to understand how single cells are able to move through constrained environments by studying the cytoskeletal regulation of cell migration. The primary aim is to investigate how evolutionarily conserved septin proteins function to enable cells, from nematodes to humans, to squeeze through tight spaces. This will involve developing specialized microscopy techniques to observe cell movement within dense tissues. In addition, the project will train undergraduate and graduate students, and develop educational modules on cell movement and microscopy for local high schools. The award period runs from September 1, 2025 to August 31, 2028, with the research being conducted by The Trustees of Columbia University in the City of New York.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/20/25 | ||
| Not listed | $1.1m | 8/18/25 |