This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This National Science Foundation Project Grant of $492,743 will fund research into the impacts of intracellular and extracellular hydraulic environments on mammalian cell migration in confined spaces. Awarded on October 15, 2022 under the Engineering program (CFDA 47.041), the funding will support mathematical modeling to decipher the coupled effects of fluid interaction with cellular structures on cell behavior in confined migration. The awardee, the Research Foundation for the State University...
This federal Project Grant award of $440,454 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support a research project focused on epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The primary objectives are to study how epithelial cells sense and respond to extracellular wounds, whether epithelial migration can occur with lower forces by modifying extracellular matrix...
This $380,000 Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research project between Northeastern University and the École Normale Supérieure in Paris, France. The project aims to develop a new generation of computational models to study eukaryotic cell motility, particularly how cells utilize "blebbing" and nuclear deformation to move through complex environments. The...
This $314,769 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports research that aims to advance the fundamental understanding of how cells and tissues communicate information about their mechanical environment. The award, effective from February 1, 2025 to January 31, 2030, will fund the development of new material platforms based on magnetic materials that can dynamically change local stiffness via magnetic fields. Experiments will explore how...
This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $192,015 to Boise State University to conduct research aimed at quantifying the mechanical forces inside living cells and determining how changes in these forces impact cellular behavior and protein production. The overarching goal is to develop predictive models and technologies that can leverage mechanical forces to guide cellular differentiation and tissue regeneration, with potential...
This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research to characterize the mechanical behavior of single cell-cell adhesions. The project aims to uncover the mechanisms governing the mechanical response of single cell-cell adhesion junctions when subjected to mechanical strains at different strain rates. The research will quantify the stress-strain relationship of a single cell pair and examine the coordinated response from the...
This National Science Foundation (NSF) Project Grant award, provided under the NSF Engineering program (CFDA 47.041), supports research to study the coordination and force transmission of beating cilia. The $284,857 award, granted on March 1, 2025, will fund a project led by The Washington University in St. Louis to investigate how coordination of cilia, which are slender structures that move fluid in the human body and single-celled organisms, is maintained and affected by changes in fluid...
The National Science Foundation (NSF) Engineering program awarded a $377,755 Project Grant to the University of New Haven, Incorporated to support fundamental research on the mechanoregulation of collective cell migration in biomimetic microenvironments. This 3-year grant, effective from September 1, 2024 to August 31, 2027, will enable the University of New Haven to investigate how mechanical forces and biochemical factors interact to regulate collective cell migration, a crucial process in...
This National Science Foundation (NSF) Biological Sciences program project grant, awarded to Oregon Health & Science University (OHSU), aims to uncover the underlying biophysical mechanisms of directed cell migration. The $1,049,497 grant, with a period of performance from January 2024 to December 2027, will examine how actin cytoskeletal networks and adhesion receptors interact as interdependent subsystems to facilitate matrix-guided cell migration, which is crucial for tissue formation and...