Project Grant 2513907
- The National Science Foundation (NSF) awarded a $450,000 Project Grant under CFDA 47.041 Engineering to North Carolina State University for a 3-year period from March 1, 2025 to February 29, 2028. The project, titled "BIOCENSORS: PARSING OUT THE GENETIC PAYLOAD OF VIRUSES BY DIFFERENTIAL BIORECOGNITION OF CAPSID FEATURES", aims to develop a biosensing technology to detect defective viral particles in gene therapy applications. The project has three key objectives: 1) studying ligand...
- This $500,000 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), supports research to develop a mathematical framework for understanding how porous materials can enhance the efficiency of viral transduction in engineered cell therapies. The award was granted to North Carolina State University (UEI: U3NVH931QJJ3) and will run from September 1, 2025 to August 31, 2028. The key objective of this project is to...
- This Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) aims to develop scalable manufacturing processes for engineered extracellular vesicles (EVs) that can serve as targeted drug delivery vehicles. The $2.55M grant to Vanderbilt University, awarded on January 1, 2024, will fund research to harness cellular processes for optimizing EV production, cargo loading, and cellular uptake. The long-term goal is to establish a biomanufacturing platform for...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $200,000 Project Grant to Lutheran University Association Inc., doing business as Valparaiso University, to develop a liposomal drug delivery platform for the treatment of lymphatic filariasis - a neglected tropical disease. The project aims to optimize the lymphatic uptake of existing lymphatic filariasis drugs and improve their efficacy against adult filarial worms. This will be achieved by synthesizing and...
- The National Science Foundation (NSF) awarded a $300,000 Project Grant to the University of Chicago for the "BRING-SYNBIO: DYNAMIC COOPERATIVE BINDERS FOR ENDOGENOUSLY GATED CELLULAR CONTROL" project under the NSF Engineering program (CFDA 47.041). This project aims to develop a new class of intrinsically disordered proteins that can directly sense environmental cues and trigger rapid, targeted changes in cellular responses, such as directing tumor cells to break apart and die. The...
- The National Science Foundation (NSF) awarded a $331,189 Project Grant under its Technology, Innovation, and Partnerships (CFDA 47.084) program to the University of Central Florida Board of Trustees. The 4-year grant, effective April 1, 2025, is focused on developing an affordable, portable platform for rapid virus detection. The innovation combines protein engineering to create stable enzymes for isothermal virus amplification, with electrochemical biosensors and microfluidics, enabling virus...
- This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program provides $987,566 to the University of California, Los Angeles (UCLA) to conduct research on viral self-assembly, from test tube to cell cytoplasm. The award period runs from December 15, 2024 to November 30, 2028. The key objectives of this project are to elucidate the differences between in vitro and in cellulo viral processes by progressively adding molecules...
- The National Science Foundation (NSF) awarded a 5-year, $695,000 Project Grant under the Engineering program (CFDA 47.041) to Case Western Reserve University (CWRU). The grant supports research to investigate the structural implications of nucleic acid nanoparticles on their transcription, translation, and transport for delivering therapeutic drug molecules or genes to cells. Key objectives include: Encoding synthetic DNA nanoparticles with gene sequences and measuring their interaction with the...
- This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), provides $357,033 to North Dakota State University (NDSU) from August 15, 2023 to July 31, 2026 to support research on protein manipulation and engineering using an electronic biochemical approach. The project aims to develop a single-molecule manipulation technique to study the dynamics of protein-protein interactions, which is critical for understanding the causes of diseases related to...
- This federal Project Grant award of $500,408 from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems supports collaborative research between Northwestern University and the University of Washington from September 2021 through August 2024. The research aims to engineer MS2 bacteriophage capsid assembly using systematic fitness landscapes, as described in the NSF Directorate for Engineering program. This program seeks to improve quality of...
The National Science Foundation (NSF) awarded a $300,000 Project Grant under CFDA 47.041 (Engineering) to Northwestern University to research and develop engineered virus-like particles (eVLPs) for drug delivery applications. The objective is to understand how cells produce and assemble eVLPs, which mimic the delivery properties of viruses but cannot replicate or cause infection. The project will also create teaching materials integrating biology, biochemistry, engineering, and computational modeling for K-12 educators. This research aims to design autonomous, dynamic genetic control circuits to optimize the self-assembly and manufacturing of eVLPs for potential therapeutic applications. The award period is from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 8/5/25 |