Project Grant 2449565
- The National Science Foundation (NSF) awarded a $331,189 Project Grant under its Technology, Innovation, and Partnerships (CFDA 47.084) program to the University of Central Florida Board of Trustees. The 4-year grant, effective April 1, 2025, is focused on developing an affordable, portable platform for rapid virus detection. The innovation combines protein engineering to create stable enzymes for isothermal virus amplification, with electrochemical biosensors and microfluidics, enabling virus...
- The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to: Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field. Achieve rapid,...
- The National Science Foundation (NSF) Directorate for Engineering awarded a $1,999,999 Project Grant under the CFDA 47.041 Engineering program to Virginia Polytechnic Institute & State University (Virginia Tech) on October 15, 2023. The objective of this 4-year project is to develop a biosensing platform that uses engineered living materials to continuously monitor for the presence of various airborne pathogens, including those that could be used as bioterrorism agents. The technology,...
- This $447,747 Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to Trustees of Boston University will develop a novel plasmonic nanosensor system to detect two important classes of RNA molecules - microRNA (miRNA) biomarkers and SARS-CoV-2 viral RNA. The sensor platform uses DNA structures with nanoparticle probes that undergo conformational changes when binding to target RNAs, altering the plasmonic coupling signal which is detected via two-color...
- This Project Grant award from the National Science Foundation's (NSF) Engineering Program (CFDA 47.041) provides $2,999,724.00 to the University of Florida to develop versatile, portable, and sensitive biosensing devices that use living cells as biosensors. The project aims to overcome limitations of current detection methods for pathogens, toxins, and biological/chemical threats by harnessing fundamental physical principles underlying modern electronic devices. Key goals include broadening...
- The National Science Foundation (NSF) awarded a $300,000 Project Grant under CFDA 47.041 (Engineering) to Northwestern University to research and develop engineered virus-like particles (eVLPs) for drug delivery applications. The objective is to understand how cells produce and assemble eVLPs, which mimic the delivery properties of viruses but cannot replicate or cause infection. The project will also create teaching materials integrating biology, biochemistry, engineering, and computational...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $275,000 will support the development of a plasmonic nanopore sensor device for quality control of adeno-associated viruses (AAVs) used in gene therapy. The proposed device will enable accurate characterization of AAV payload (single-stranded DNA, double-stranded DNA, or empty) at low, pre-scale-up concentrations to optimize formulations. The project aims to demonstrate the...
- This $500,000 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), supports research to develop a mathematical framework for understanding how porous materials can enhance the efficiency of viral transduction in engineered cell therapies. The award was granted to North Carolina State University (UEI: U3NVH931QJJ3) and will run from September 1, 2025 to August 31, 2028. The key objective of this project is to...
- This $495,516 project grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a next-generation, ultrasensitive, and easy-to-use diagnostic platform for detecting nucleic acids. The project merges advances in nanomaterials, sensor engineering, and gene-editing-inspired detection to enable accurate and rapid identification of nucleic acids without the need for complex laboratory procedures. Key innovations include signal amplification through...
- The Ohio State University received a $249,999 Project Grant award from the National Science Foundation Division of Industrial Innovation on June 15, 2021 to develop DNA sensors for rapid detection of COVID-19 and other viral diseases. Funded under the NSF Engineering program (CFDA 47.041), this award will support The Ohio State University Office of Sponsored Programs in engineering research to improve viral detection technologies. Specifically, the University will work to create novel DNA...
The National Science Foundation (NSF) awarded a $450,000 Project Grant under CFDA 47.041 Engineering to North Carolina State University for a 3-year period from March 1, 2025 to February 29, 2028. The project, titled "BIOCENSORS: PARSING OUT THE GENETIC PAYLOAD OF VIRUSES BY DIFFERENTIAL BIORECOGNITION OF CAPSID FEATURES", aims to develop a biosensing technology to detect defective viral particles in gene therapy applications. The project has three key objectives: 1) studying ligand interactions with full and empty viruses, 2) integrating the ligands with biosensors to create an electrochemical dictionary for interpreting binding events, and 3) validating the technology with therapeutic viruses. This research could enable more accurate quantification of viral titer and gene loading, which is critical for assessing viral infectivity and ensuring the safety and efficacy of gene therapies. The project will engage the biotech and biopharma communities to foster adoption of the biosensing technology in research and industry.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $450.0k | 6/20/25 |