The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded a $200,000 Project Grant to Lutheran University Association Inc., doing business as Valparaiso University, to develop a liposomal drug delivery platform for the treatment of lymphatic filariasis - a neglected tropical disease. The project aims to optimize the lymphatic uptake of existing lymphatic filariasis drugs and improve their efficacy against adult filarial worms. This will be achieved by synthesizing and characterizing a panel of liposomes with controllable properties to enhance drug delivery to the lymphatic system after oral administration. The project will also investigate the impact of liposome characteristics on drug toxicity against adult filarial worms in vitro. Additionally, this research will be paired with the development of laboratory activities on topics like cell culture, nanomaterials, and analysis tools for implementation in undergraduate engineering courses. The award period runs from Sep 1, 2024 to Aug 31, 2026.
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