This $435,054 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research and development of a solid-state nanopore-based point-of-care nucleic acid testing device. The award aims to address key challenges in translating solid-state nanopore sensors to practical settings, including reproducible size control, introducing specificity, prolonged sensing time at low analyte concentrations, and integrated sample preparation. The research...
This National Science Foundation (NSF) Project Grant award under CFDA 47.041 - Engineering aims to develop a new sensing mechanism and approach for a nanopore sensor that can provide ultrasensitive and selective detection of various small molecules, including small biomolecules and bioactive molecules, at the single-molecule level under physiological conditions. The $442,106 award to Florida International University, a Hispanic-Serving Institution, will fund research with two main tasks: (1)...
The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to: Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field. Achieve rapid,...
This National Science Foundation (NSF) CAREER award, provided under CFDA 47.041 Engineering, is focused on developing calibration-free potentiometric sensors for biofluid analysis. The $476,445 award, granted on May 15, 2025, will support the development of ready-to-use sensing platforms and prototypes through the functionalization of 3D-printed materials. The project aims to leverage the benefits of additive manufacturing, such as reproducibility, spatial control, and mass production...
This $425,118 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) will fund the development of a new portable biosensor capable of detecting known and emerging environmental toxins, chemical agents, and biological threats. The project aims to create a biosensor that can rapidly identify toxins, including those that have never been characterized before, by monitoring the real-time responses of specialized microbial...
This $448,818 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a miniaturized, sensitive, and user-friendly electromagnetic (EM) biosensing platform to rapidly detect and identify bacterial infections. The project combines physics-based dielectric spectroscopy and biochemistry-based magnetic nanoparticle detection to capture unique signatures of various bacterial strains. Key innovations include: 1) ultrasensitive biosensing...
This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) is focused on developing a new, affordable technology to test for viruses with high accuracy. The $331,189 project, awarded on April 1, 2025, employs protein engineering to create stable enzymes that can be stored at room temperature and used with electrochemical biosensors and microfluidics technology to create a portable, cost-effective virus detection...
This $447,747 Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to Trustees of Boston University will develop a novel plasmonic nanosensor system to detect two important classes of RNA molecules - microRNA (miRNA) biomarkers and SARS-CoV-2 viral RNA. The sensor platform uses DNA structures with nanoparticle probes that undergo conformational changes when binding to target RNAs, altering the plasmonic coupling signal which is detected via two-color...
This National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) Federal Grant Program (CFDA 47.070) award of $1,200,000 provides funding to the University of California, Berkeley from October 1, 2024 to September 30, 2028 to develop innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics for next-generation diagnostics. The key objectives of this project grant are to: (1) develop molecular engineering techniques using DNA origami...
This $430,785 National Science Foundation (NSF) CAREER award to the Regents of the University of California at Riverside (UC Riverside), awarded under the NSF Engineering program (CFDA 47.041), is focused on developing novel CRISPR-based biosensing technologies for the ultra-accurate detection of disease-related single nucleotide polymorphisms (SNPs). The central goals of the 5-year project are to: 1) enable ultra-accurate SNP detection using a CRISPR-Cas14 biosensor, 2) design a ratiometric SNP...