The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to:
Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field.
Achieve rapid, high-sensitivity nucleic-acid detection by integrating the nanomechanoelectrical transduction with transversal electrophoresis.
This highly innovative research aims to overcome limitations of existing nucleic-acid detection techniques by creating compact, quick, accurate, and user-friendly devices. The project also includes an educational outreach component to engage students across all levels, with a focus on underrepresented groups in STEM fields. The expected outcomes include advancements in bioengineering and rapid, accurate point-of-care nucleic-acid testing that could enhance pandemic management and global healthcare.