Project Grant 2421137
- This National Science Foundation Project Grant of $180,493 will support the development of an ultrasensitive point-of-care diagnostic system using clustered regularly interspaced short palindromic repeats (CRISPR) technology for early disease detection without pre-amplification of viral genomes. Funded under the NSF's Office of Integrative Activities program (CFDA 47.083), which enhances STEM competitiveness through capacity building and broadening participation, this 24-month project will...
- The National Science Foundation awarded a $199,999 Project Grant under the Engineering (CFDA 47.041) program to The Trustees of the University of Pennsylvania to develop a next-generation RNA detection tool for infectious disease diagnosis. The project aims to engineer a thermostable version of the CRISPR-Cas13 enzyme to improve its stability and sensitivity for field applications. By combining the enhanced Cas13 enzyme with advanced electrochemical devices, the researchers will create an...
- This $199,997 federal Project Grant, awarded by the National Science Foundation's Engineering program (CFDA 47.041), aims to improve the stability and sensitivity of a heat-resistant version of the CRISPR-Cas13 enzyme for rapid and accurate detection of disease-causing RNA. The collaborative research project between William Marsh Rice University and its partners will leverage mechanism-based protein engineering and electrochemical devices to generate next-generation RNA detection tools for...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program totaling $100,000 will support research to develop next-generation clustered regularly interspaced short palindromic repeat (CRISPR) systems for curing inherited diseases. Specifically, the awardee, the University of California, Berkeley, will work to circumvent in vivo delivery challenges with CRISPR-Cas9 by developing miniature RNA-guided genome editors smaller than Cas9 that can be...
- This National Science Foundation Project Grant, funded under the Engineering program (CFDA 47.041), aims to improve the stability and sensitivity of a heat-resistant version of the CRISPR-Cas13 enzyme for accurate and robust detection of disease-causing RNA. The $200,000 award, effective November 1, 2024 through October 31, 2027, supports the University of Connecticut's efforts to engineer the Cas13 enzyme for enhanced thermostability, protease resistance, and target sensitivity. The...
- This CAREER award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports an integrated research and education project to address fundamental and applied challenges in solid-state nanopore-based single molecule counting platforms for point-of-care nucleic acid testing. The $435,054 award, effective from January 1, 2025 to May 31, 2026, aims to develop a fully integrated solid-state nanopore digital counting system for decentralized nucleic acid testing...
- The National Science Foundation (NSF), under its Engineering program (CFDA 47.041), awarded a $429,832 Project Grant to the University of Massachusetts (UMass) to develop a novel method for rapid and sensitive detection of nucleic acids such as DNA and RNA. The main objectives of the 5-year project are to: Determine the nanomechanoelectrical transduction principle of nucleic-acid nanostructures tethered to a graphene transistor and oscillating in an electric field. Achieve rapid,...
- This National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) Federal Grant Program (CFDA 47.070) award of $1,200,000 provides funding to the University of California, Berkeley from October 1, 2024 to September 30, 2028 to develop innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics for next-generation diagnostics. The key objectives of this project grant are to: (1) develop molecular engineering techniques using DNA origami...
- The National Science Foundation awarded $905,966 under the Engineering (47.041) federal grant program to The Regents of the University of California, Berkeley from June 15, 2022 to May 31, 2027. The award will support the development and validation of a targeted long-read DNA sequencing approach to enable enrichment of antibiotic resistance genes and flanking regions from metagenomic samples. This is intended to facilitate detection of low-abundance antibiotic resistance gene targets and their...
- This $495,516 project grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a next-generation, ultrasensitive, and easy-to-use diagnostic platform for detecting nucleic acids. The project merges advances in nanomaterials, sensor engineering, and gene-editing-inspired detection to enable accurate and rapid identification of nucleic acids without the need for complex laboratory procedures. Key innovations include signal amplification through...
This $430,785 National Science Foundation (NSF) CAREER award to the Regents of the University of California at Riverside (UC Riverside), awarded under the NSF Engineering program (CFDA 47.041), is focused on developing novel CRISPR-based biosensing technologies for the ultra-accurate detection of disease-related single nucleotide polymorphisms (SNPs). The central goals of the 5-year project are to: 1) enable ultra-accurate SNP detection using a CRISPR-Cas14 biosensor, 2) design a ratiometric SNP detection approach using biorthogonal CRISPR-Cas13 systems, and 3) demonstrate CRISPR-Cas12 array sensors to simultaneously identify multiple SNPs. The project aims to leverage CRISPR technology's capabilities for precise nucleic acid detection to advance disease diagnostics and monitoring. Additionally, the grant supports educational and outreach efforts to broaden participation in biotechnology careers and provide hands-on training for undergraduate and graduate students.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.8k | 3/18/24 |