Project Grant 2434524

Award Date 5/15/25
Completion Date 4/30/28
Dollars Obligated $442K
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Miami, FL 33199, USA
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This National Science Foundation (NSF) CAREER grant award under the Engineering program (CFDA 47.041) provides $242,687 to the University of Massachusetts to develop an ultrasensitive nanopore biosensor technology for point-of-care detection of infectious disease biomarkers. The key objectives are to: (1) optimize a highly sensitive and robust nanopore sensor, (2) enable specific biomarker detection using automated immunoprecipitation and novel signal transduction, and (3) demonstrate...
This $435,054 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research and development of a solid-state nanopore-based point-of-care nucleic acid testing device. The award aims to address key challenges in translating solid-state nanopore sensors to practical settings, including reproducible size control, introducing specificity, prolonged sensing time at low analyte concentrations, and integrated sample preparation. The research...
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The $442,106 award to Florida International University, a Hispanic-Serving Institution, will fund research with two main tasks: (1) understanding the unique ionic signals induced by self-crowding at the nanopipette tip, and (2) developing a small molecule sensing approach based on ligand binding. The proposed approach has the potential to address major challenges in nanopore sensing by slowing down the detection of small molecules in the nanopipette sensing zone through self-crowding. The project will also provide opportunities for academic training and STEM outreach programs. The award period is from May 15, 2025 to April 30, 2028.

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