This Project Grant award of $374,999.00 from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program supports research to investigate the mechanisms that enable analog information storage in the chromatin state of cells. The University of California, San Diego (UCSD) is the primary awardee and will collaborate with the Massachusetts Institute of Technology on this 4-year project. The key objectives are to develop a model-driven understanding of how the...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) provides $481,237 to the Massachusetts Institute of Technology (MIT) to develop reversible long-term memory devices in bacterial cells. The key products and services to be delivered include: Demonstrating the engineering of a circuit motif in bacteria that mimics processes associated with long-term memory of chromatin states in...
The National Science Foundation awarded a $760,000 project grant to the Massachusetts Institute of Technology from February 1, 2021 through January 31, 2024. The grant is part of NSF's Biological Sciences program (CFDA 47.074) to promote advancement in the biological sciences. Under the award, MIT researchers will investigate protein regulators of three-dimensional genome architecture, dynamics, mechanism and function. Specifically, the grant will fund research into how proteins control the...
This $573,937 five-year Project Grant was awarded on February 1, 2024 by the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The grant will fund research at the Massachusetts Institute of Technology (MIT) to understand how changes in DNA structure impact the behavior of synthetic gene circuits and gene expression more broadly. The project aims to develop a better understanding of supercoiling-mediated...
The National Science Foundation awarded a $367,636 Project Grant to the Massachusetts Institute of Technology from March 1, 2021 through February 29, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research on multidimensional single-cell phenotyping to elucidate relationships between genomes and phenotypes. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award supports...
The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...
This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems Project Grant of $500,000 awarded to Beth Israel Deaconess Medical Center, Inc. (Bidmc) aims to develop a novel, label-free method for dynamically sensing chromatin packing and structure in live cells. The 3-year project leverages the principles of fractal sensing and coherent confocal light absorption and scattering spectroscopic microscopy to create a 3D dynamic map of chromatin...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
The National Science Foundation (NSF) awarded a 5-year, $399,835 CAREER grant under the Biological Sciences program (CFDA 47.074) to the Massachusetts Institute of Technology (MIT) to investigate how transcription and loop extrusion regulate 3D genome structure. The project aims to improve the understanding of how a single genome gives rise to diverse cell types by studying the dynamics of CTCF-mediated DNA loops and topologically associating domains (TADs). The work will integrate advanced...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program provides $242,103 to the Massachusetts Institute of Technology (MIT) to conduct research exploring how proteins and lipids coordinate the formation and function of membrane-associated condensates. The goal is to gain a better understanding of how the cell surface is organized, which could lead to advancements in biotechnology, disease treatment, and our overall understanding of...