This $410,939 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to elucidate the biophysical mechanisms of membrane protein folding and stability through advanced single-molecule force spectroscopy. The research project aims to develop new methods to study these essential cellular proteins by probing them with applied mechanical force at the single-molecule level. Key objectives include understanding how protein and...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to:
Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions.
Directly relate the observed domain unfolding of...
Under this $200,000 Project Grant from the National Science Foundation Division of Chemistry's Mathematical and Physical Sciences program (CFDA 47.049), the New Jersey Institute of Technology will collaborate with the University of Rochester and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The collaborative team will determine the structure of these systems with near-atomic precision using cryo-electron...
This $1,200,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports the development of a time-resolved cryo-electron microscopy (cryo-EM) method to study the dynamics of diverse biological molecules. The principal investigator will collaborate with three renowned scientific laboratories to apply this technique to investigate the structural changes over time of RNA polymerase, the GLP1R receptor, and the AcrB multi-drug...
This $374,720 federal Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences (CFDA 47.049) program, supports research by Professor David Dearden and his team at Brigham Young University (BYU) to develop new tools for measuring the folding and unfolding of isolated molecules. The goal is to better understand how molecular structure correlates with the energy and kinetics associated with folding and unfolding, which...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $221,474 Project Grant to the University of Vermont & State Agricultural College (UVM) for the period of August 1, 2023 to July 31, 2026 under the Biological Sciences program (CFDA 47.074). The primary objective of this grant is to enable the principal investigator to acquire expertise in utilizing single-particle cryo-electron microscopy (cryo-EM) techniques to elucidate the molecular...
This $285,570 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at the University of Vermont & State Agricultural College (UVM) to investigate living tissues as adaptive materials. The project aims to understand how cellular adaptability influences the mechanical properties and behaviors of tissues, with potential applications in areas like wound healing, cancer, and the development of biomimetic materials.
The research will...
The National Science Foundation (NSF) awarded a $100,000 Project Grant to Rutgers, The State University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The 3-year grant supports a collaborative U.S.-France research project to develop new experimental and analytical methods for probing the heterogeneity of biological systems at the molecular level. Key deliverables include: 1) advanced high-speed atomic force spectroscopy techniques to study the complex structural...
The National Science Foundation (NSF) Division of Chemistry awarded a $420,000 Project Grant to the University of Utah from August 1, 2023 to July 31, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The funding supports the development of a novel optical biosensor capable of detecting and quantifying a wide range of biological molecules, including biomarkers found in bodily fluids. The project leverages second harmonic generation (SHG) and optical heterodyning...
This $200,000 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of innovative fluorinated protein fibers and hydrogels for medical applications at New York University (NYU) School of Medicine. The key objectives are to: 1) generate coiled-coil fluorinated fibers for controlled drug delivery, 2) create temperature-responsive fluorinated hydrogels, and 3) assess the potential of these fluorinated...