Project Grant 2321501
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded The Trustees of Columbia University in the City of New York a $1,200,000 Project Grant on March 15, 2025 to develop and apply a method of time-resolved cryo-electron microscopy (cryo-EM) to diverse biological molecules of medical importance. The project aims to use newly designed PDMS-based microfluidic chips to apply the time-resolved cryo-EM sample preparation technique, which has been...
- The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $500,176 to Eastern Michigan University (EMU) will advance fundamental understanding of the molecular mechanisms regulating gene expression. The 3-year project will study the structure and function of the UHRF1 and UHRF2 epigenetic regulator proteins, which play critical roles in processes like cell cycle control and DNA repair. The research aims to elucidate differences in histone binding...
- The University of Utah will receive $492,516 from the National Science Foundation Division of Molecular and Cellular Biosciences under a three-year Project Grant award titled "Role of Electric Fields and a Dynamic Local Environment in Protein-RNA Molecular Recognition." The grant funds basic research from August 1, 2021 to July 31, 2024 to advance understanding of major problems in the biological sciences by investigating the role of electric fields and the local molecular...
- The University of Vermont & State Agricultural College (UVM) received a $298,981 Project Grant award from the National Science Foundation (NSF) Division of Environmental Biology under the Biological Sciences program (CFDA 47.074). The grant will fund a collaborative research project to investigate how alpine plant communities in the Northeastern United States have responded to climate change over the past 13,000 years. Through a multi-faceted approach integrating paleoecology, community...
- The National Science Foundation awarded a $357,365 Project Grant to the University of Denver under the Biological Sciences federal grant program (CFDA 47.074) for work titled "COLLABORATIVE RESEARCH: CIBR: INCORPORATING CRYSTALLOGRAPHY AND CRYO-EM TOOLS IN FOLDIT." The three-year award running from June 2021 through May 2024 will support research incorporating crystallography and cryo-electron microscopy tools to advance protein structure prediction. The Biological Sciences program...
- The National Science Foundation (NSF) has awarded a $741,544 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate how dormant yeast cells reorganize their cellular machinery, particularly the ribosomes that produce proteins. The principal investigators, Dr. Ahmad Jomaa at the University of Virginia and Dr. Simone Mattei at the EMBL Imaging Center in Germany, will use advanced imaging and molecular biology techniques to understand how ribosomes become inactive by...
- This National Science Foundation Project Grant of $600,000 will support research at Cornell University from June 2022 through May 2024 under the Biological Sciences program (CFDA 47.074). The university will conduct cryogenic electron microscopy analysis of the chloroplast CLP protease system in Arabidopsis thaliana to determine the three-dimensional structure of the endogenous ~1,000 kDa CLP protease-chaperone complex. The research aims to unravel the structural details of this chloroplast...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $949,953 Project Grant to the Research Foundation Of The City University Of New York, doing business as Rfcuny - Hunter College, from August 1, 2023 to July 31, 2026. The grant, funded under the Biological Sciences program (CFDA 47.074), will support research to identify molecular interactions and build a detailed model of translational regulation, specifically examining the role of eIF3 and 4E-BP in...
- The National Science Foundation (NSF) awarded a $630,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to the University of New Mexico (UNM) to develop an advanced optical microscopy system. The project aims to significantly improve the study of protein clustering and interactions on cell membranes, which could advance the understanding of cell signaling and related diseases like cancer. The highly interdisciplinary research will combine the MINFLUX and modal...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $221,474 Project Grant to the University of Vermont & State Agricultural College (UVM) for the period of August 1, 2023 to July 31, 2026 under the Biological Sciences program (CFDA 47.074). The primary objective of this grant is to enable the principal investigator to acquire expertise in utilizing single-particle cryo-electron microscopy (cryo-EM) techniques to elucidate the molecular structures of large proteins and oligomeric complexes related to gene regulatory mechanisms. Specifically, the project will investigate how chromatin reader domains, such as the bromodomain, interact with post-translational modifications on histone proteins and the nucleosome to regulate essential DNA-templated processes. Through partnerships with the University of Michigan and the National Center for Cryo-EM Access and Training, the PI will develop data processing and training workflows to determine the structures of chromatin regulatory complexes. This collaborative effort will also be utilized to develop new educational and training resources to facilitate broader access to cryo-EM technology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $221.5k | 7/7/23 |