This $543,251 federal Project Grant award, provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049), supports research by Professor Jessica Kramer at the University of Utah to develop chemically tunable models of the cellular glycocalyx. The glycocalyx is a protein and sugar coating on cell surfaces that plays crucial biological roles, particularly in mucin-rich regions like the eyes, lungs, and gastrointestinal...
This Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $450,000 to Montana State University from November 2022 through October 2025. The funding supports research by Professor Mary Cloninger to develop sugar-modified, highly branched compounds called glycodendrimers to study the roles of galectins in cell-to-cell interactions. Specifically, Dr. Cloninger and her team will synthesize...
The National Science Foundation (NSF) awarded a $536,604 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to Saint Louis University. The grant, awarded on July 1, 2024, will support research by Professor Alexei Demchenko to develop new methods for stereocontrolled glycosylation. The project aims to investigate mechanistic and practical aspects of two novel glycosylation reactions, the cooperatively catalyzed Koenigs-Knorr (4K) reaction and the H-bond-mediated...
This $399,562 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will fund research by Mississippi State University to understand how natural and synthetic polyelectrolytes (charged polymers) respond to applied electric fields. The key objectives are to: Investigate the electrochemical processes that control the formation and deposition of polyelectrolyte complexes, and Elucidate how electric fields impact the...
The National Science Foundation (NSF) awarded a $513,894 Project Grant under its Mathematical and Physical Sciences program (CFDA 47.049) to Tufts University. This 3-year grant, effective July 1, 2023, supports Professor Clay S. Bennett's research to develop new methods for synthesizing deoxy sugars - an important component of many biologically active natural products. The project aims to expand upon approaches that activate sugar hemiacetals as glycosyl sulfonates or tert-butyldimethylsilyl...
The National Science Foundation (NSF), through its Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), has awarded a $599,879 Project Grant to Professor Wenqi Liu at the University of South Florida (USF). This 5-year grant, effective August 1, 2024, aims to investigate molecular recognition in water mediated by hydrogen bonding. The research seeks to uncover design principles that enable synthetic receptors to effectively utilize hydrogen...
This $306,532 federal Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will fund research at Yale University to investigate the role of molecular motions in the allosteric activation of the enzyme imidazole glycerol phosphate synthase. The project will utilize advanced field cycling nuclear magnetic resonance spectroscopy techniques, coupled with computational modeling, to gain unprecedented insights into the timescales and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the University of Mississippi's work to develop a generalized strategy for the synthesis of complex sulfoglycopeptide molecules. The $357,646 award, running from July 1, 2024 to May 31, 2029, will enable the university to: 1) Build compound libraries to map the relationship between co-localized sulfation and glycosylation patterns and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $382,500.00 in funding to the Texas A&M Engineering Experiment Station (Tees) to investigate the role of membrane dynamics in cell surface glycan recognition. The key research objectives are to: 1) Understand how the spatial organization of glycan ligands on the cell membrane influences glycobiology processes, using...
This $299,396 National Science Foundation project grant supports research into the role of lipids in modulating synaptic plasticity of ion channels. Funded under the Biological Sciences program (CFDA 47.074), the two-year award to the University of Tennessee will elucidate the microscopic mechanisms involved in ion transport across membrane-associated protein channels. Researchers will focus on dynamic and structural features of biological membranes and leverage non-invasive scattering...