The National Science Foundation (NSF) awarded a $536,604 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to Saint Louis University. The grant, awarded on July 1, 2024, will support research by Professor Alexei Demchenko to develop new methods for stereocontrolled glycosylation. The project aims to investigate mechanistic and practical aspects of two novel glycosylation reactions, the cooperatively catalyzed Koenigs-Knorr (4K) reaction and the H-bond-mediated aglycone delivery (HAD) reaction. The research seeks to streamline the synthesis of biologically relevant glycan targets, which could facilitate fundamental studies in chemical biology and the development of diagnostic and therapeutic agents. The project will also provide research opportunities and training for students at various education levels.
Generated 12/31/24, 1:04 PM