Project Grant 2246963

Award Date 7/1/23
Completion Date 6/30/26
Dollars Obligated $514K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Medford, MA 02155, USA
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The project aims to expand upon approaches that activate sugar hemiacetals as glycosyl sulfonates or tert-butyldimethylsilyl glycosides. These methods enable the controlled synthesis of deoxy sugar oligosaccharides with high stereoselectivity. The research will investigate the generality and mechanisms of these reactions through the synthesis of diverse oligosaccharides and kinetic isotope experiments. This work has the potential to significantly impact academic and industrial laboratories in the agricultural, chemical, and pharmaceutical sectors. The grant also provides valuable training for undergraduate and graduate students, as well as outreach to engage high school students in organic chemistry.

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