The National Institute of General Medical Sciences (NIGMS) awarded a five-year, $357,646 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Mississippi to support the development of a generalized strategy for the synthesis of chemoenzymatic libraries of sulfoglycopeptides. The project aims to: (1) build compound libraries to map the relationship between co-localized tyrosine sulfation and O-glycosylation patterns and their corresponding binding/signaling pathways; (2) use the structure-defined sulfoglycopeptides to develop reliable characterization methods for these post-translational modifications across different proteins; and (3) leverage computational chemistry to predict meaningful binding interactions and design probes/molecules targeting specific binding events. This work will advance the understanding of how cells use the fine-tuning of these co-localized modifications to regulate critical biological processes and pathways.
Generated 2/25/25, 3:47 AM