How are regenerating axons guided in the adult nervous system
Ended Project Grant Awarded Last action
- Award ID
- F31NS139608
- Recipient
-
University Of Massachusetts Medical School UEI MQE2JHHJW9Q8
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $52,164
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date
- Place of performance
- Worcester, MA 01655, USA
Award details come from USAspending.gov.
Description
- Abstract
- Common nerve injuries often lead to long-term disabilities in the central nervous system and in the peripheral nervous system with increased adult age. Understanding how axon guidance is regulated in the mature nervous system is critical to understanding how the nervous system changes after development and to developing therapies aimed at reestablishing proper neural circuitry across lesions. Caenorhabditis elegans is a highly tractable model to dissect conserved molecular and cellular mechanisms that regulate axon regeneration and axon guidance. With this system, i have identified an extracellular matrix protein that guides regenerating motor axons specifically in the post-development nervous system and is required for functional recovery. I will apply my developing skills in detailed genetic analyses, laser axotomy, in vivo imaging, sequencing, and bioinformatics to further determine the post-developmental specific role of this protein in axon guidance. In addition to providing a critical advance in understanding the fundamental mechanisms of axon guidance, IT will also inform future therapeutic approaches that can be manipulated to promote targeted axon guidance in the injured adult nervous system.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | -$262 | |
| Amendment | -$24,205 | |
| Amendment | -$24,205 | |
| Amendment | $564 | |
| Amendment | $564 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $33,236 | |
| Amendment | $33,236 | |
| Original award | $33,236 |
Quick answers
Who received award F31NS139608?
F31NS139608 was awarded to University Of Massachusetts Medical School by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on November 1, 2025.
How much is award F31NS139608 worth?
$52,164 has been obligated on F31NS139608.
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