This $900,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at the University of Colorado (CU) to investigate the molecular mechanisms of DNA methyltransferase 1 (DNMT1)-mediated gene silencing. The project aims to utilize structural biology, biochemistry, and cell biology methods to understand DNMT1 regulation and the mechanisms cells employ to ensure DNMT1 acts on specific DNA sequences. The research will provide...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $1,199,999.00 to the University of Southern California (USC) to study the molecular mechanisms of DNA N6-adenine methylation (6mA) in the unicellular eukaryote Tetrahymena thermophila. The research aims to map the genomic distribution of 6mA, elucidate the mechanisms of how this epigenetic mark is deposited, and explore its role in gene regulation and potential implications...
This $452,399 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Hofstra University to investigate the epigenetic regulation of transposable elements in maize. The research aims to study the RNA-directed DNA methylation (RDDM) induced by naturally occurring maize "killer" alleles and explore the dynamic regulation of transposable element silencing in response to developmental cues. The project will...
This $1,226,250 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the role of DNA methylation in regulating retrotransposons and governing adult stem cell fate decisions. The award to the University of Texas MD Anderson Cancer Center will fund a 5-year study using mouse skin as a model system to: (1) elucidate the molecular mechanisms underlying DNA and...
This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
This National Science Foundation (NSF) CAREER award under the Biological Sciences (CFDA 47.074) program provides $171,061 to the University of Texas at Arlington (UTA) from February 15, 2025 to January 31, 2030. The project aims to uncover the mechanistic details of how RNA interference (RNAi) and chromatin modifying pathways interact to maintain appropriate gene regulation during stress in the C. elegans germline model system. The research will advance understanding of the epigenetic and...
The University of Texas at Dallas received a $294,647 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award, with a period of performance from September 1, 2024 to August 31, 2028, will support the development of a theoretical, computational, and experimental framework to model epigenetic regulatory networks in human cells. The project aims to assemble and stably integrate...
This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...
The University of Georgia Research Foundation, Inc. received a $880,000 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The three-year award running from July 1, 2023 to June 30, 2026 will support research investigating the mechanistic origins and evolution of gene body DNA methylation in plant models. Specifically, the grantee will explore the roles of histone...
This $246,424 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to define the initiation and early steps of recombination at DNA double strand breaks in human cells. The research aims to leverage novel methods to understand how cells choose different DNA repair mechanisms, with implications for fields like gene editing, cancer treatment, and personalized medicine. Additionally, the project will provide training...