This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $1,199,999 provides funding to the University of Southern California (USC) to study the molecular mechanisms of DNA N6-adenine methylation (6mA) in the unicellular eukaryotic model organism Tetrahymena thermophila. The research aims to gain insights into how this epigenetic DNA modification is involved in gene regulation and transcription, with potential implications for understanding health and disease.
The project will use advanced DNA sequencing techniques to map 6mA across the Tetrahymena genome, and will investigate the molecular targeting mechanisms that deposit and transmit 6mA in the context of transcription and chromatin. The findings from this work are expected to provide deep insights into the biology of 6mA in eukaryotic cells. The award also includes strong educational and community outreach components to train the next generation of scientists in this important research area. Subawards are planned as part of this project.
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