Project Grant 2427812

Award Date 7/15/24
Completion Date 6/30/27
Dollars Obligated $254K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Phillips Ranch, CA 91766, USA
Similar Awards
This award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $741,000 to the University of Chicago to develop a fast and accurate computational tool called UPSIDE for simulating the dynamics and structure of large membrane proteins involved in sensing environmental stimuli like force and heat. The research aims to enhance the understanding of how sensory membrane proteins in humans and animals function at the atomic level, which is crucial for addressing...
The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
This $795,135 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Illinois on protein dynamics under extreme environmental conditions. The four-year award beginning June 1, 2022 will fund three related subprojects investigating how proteins adapt to enable organism survival in stressful environments like heat, pressure and dehydration. The research will study intrinsically disordered protein structure and...
This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to: Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions. Directly relate the observed domain unfolding of the...
This $659,728 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will support the development of the BioMemBHub cyberinfrastructure. BioMemBHub is designed to advance modeling and analysis capabilities for biomembranes, proteins, peptides, and small molecules. The project will create an integrated platform consisting of seven web servers and three large databases to enable exploration of the structural and dynamic aspects of...
The National Science Foundation (NSF) awarded a $150,000 Project Grant under the Computer and Information Science and Engineering (CFDA 47.070) federal grant program to the University of Missouri System. The grant, titled "COLLABORATIVE RESEARCH: ACED: DEVELOPING CONSISTENCY MODEL-BASED ULTRA-LONG STRIDE MOLECULAR SIMULATION TO UNRAVEL LONG-TIME DYNAMICS OF PROTEINS", aims to develop deep learning-based consistency models to simulate the long-time scale dynamics of protein structures...
This $410,939 federal Project Grant award was provided by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program. The grant aims to develop new methods for studying the biophysical mechanisms of membrane protein folding and stability through advanced single-molecule force spectroscopy. The research will use atomic force microscopy to measure the forces that hold membrane proteins in their functional, folded shapes, addressing fundamental questions about how...
This $383,799 National Science Foundation project grant supports collaborative research to map protein-membrane interactions across molecular to cellular scales. Funded under the Biological Sciences program (CFDA 47.074), the research aims to better understand how integral membrane proteins and surrounding phospholipid membranes work together to enable cellular processes. The University of Arizona will conduct multiscale modeling from molecular dynamics simulations of single protein-membrane...
The National Science Foundation (NSF) awarded a $568,480 Project Grant under the Engineering (CFDA 47.041) program to The Regents of the University of Colorado, doing business as the University of Colorado, to conduct research on a novel biosensing concept for high-sensitivity measurement of cell mechanical biomarkers. The 3-year award, effective May 1, 2024, will investigate how biological cells with different mechanical properties interact with acoustic waves propagating along a substrate, and...

The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation by HD Exchange," aims to enhance the understanding of how biological sensors function at the atomic level, providing insights into environmental sensing, ion channels, and protein folding. The award period is from July 15, 2024, to June 30, 2027. The research will involve the training of graduate students and postdoctoral scholars, contributing to the development of a diverse STEM workforce.

Generated 4/8/25, 5:40 AM